Quantified neurophysiology with mapping: statistical inference, exploratory and confirmatory data analysis

Brain Topography
F H DuffyH Als

Abstract

Topographic mapping of brain electrical activity has become a commonly used method in the clinical as well as research laboratory. To enhance analytic power and accuracy, mapping applications often involve statistical paradigms for the detection of abnormality or difference. Because mapping studies involve many measurements and variables, the appearance of a large data dimensionality may be created. If abnormality is sought by statistical mapping procedures and if the many variables are uncorrelated, certain positive findings could be attributable to chance. To protect against this undesirable possibility we advocate the replication of initial findings on independent data sets. Statistical difference attributable to chance will not replicate, whereas real difference will reproduce. Clinical studies must, therefore, provide for repeat measurements and research studies must involve analysis of second populations. Furthermore, Principal Components Analysis can be employed to demonstrate that variables derived from mapping studies are highly intercorrelated and data dimensionality substantially less than the total number of variables initially created. This reduces the likelihood of capitalization on chance. The need to constrain a...Continue Reading

References

Jun 1, 1976·Electroencephalography and Clinical Neurophysiology·R N KavanaghD H Fender
Jan 1, 1979·Medical & Biological Engineering & Computing·A Maus, J Endresen
Jan 21, 1977·Journal of Chromatography·J W Aston
Jan 1, 1988·Brain Topography·K L Coburn, M A Moreno
Jan 1, 1988·Brain Topography·P Rappelsberger, H Petsche
Mar 15, 1988·Biological Psychiatry·E M KahnR Coppola
Oct 1, 1987·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J Santamaria, K H Chiappa
Jul 1, 1988·Clinical EEG (electroencephalography)·S A Jerrett, J Corsak
May 1, 1986·Annals of Neurology·B S Oken, K H Chiappa
Oct 1, 1987·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M R Nuwer, S E Jordan
Nov 15, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·H Skalka, J Holman
Jan 31, 1986·Documenta Ophthalmologica. Advances in Ophthalmology·H W SkalkaJ Holman
Jan 1, 1973·Electroencephalography and Clinical Neurophysiology·E R JohnJ Gehrmann
Jul 1, 1970·IEEE Transactions on Bio-medical Engineering·A Van Rotterdam
May 1, 1981·Electroencephalography and Clinical Neurophysiology·F H DuffyJ L Burchfiel
Oct 1, 1983·Electroencephalography and Clinical Neurophysiology·R MorstynR W McCarley
Oct 1, 1984·Annals of Neurology·F H DuffyA J Garvey
Jul 1, 1983·Archives of General Psychiatry·J M MorihisaR J Wyatt
Jul 1, 1983·Archives of General Psychiatry·R MorstynR W McCarley
May 1, 1981·Controlled Clinical Trials·K Abt

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Citations

Jan 1, 1992·Brain Topography·R B Silberstein, P J Cadusch
Jan 1, 1992·Brain Topography·P ValdésR Biscay
Jan 1, 1994·Brain Topography·L GalánT Virues
Jun 1, 1995·Psychopharmacology·H ShikataT Sakaki
Jun 1, 2005·Australasian Physical & Engineering Sciences in Medicine·H A SadafiA W Wood
Jan 1, 1995·Electroencephalography and Clinical Neurophysiology·R B SilbersteinA Pipingas
Nov 1, 1995·Electroencephalography and Clinical Neurophysiology·A Fernández-BouzasM Alonso
Sep 1, 1989·Psychiatry Research·F H Duffy
Sep 19, 1998·Electroencephalography and Clinical Neurophysiology·G F DíazP Valdés
Aug 30, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J C ThompsonR B Silberstein
Aug 26, 1998·Electroencephalography and Clinical Neurophysiology·D E BeckerC D Yingling
Oct 1, 1992·Pathology, Research and Practice·R L BeckerT J O'Leary
Apr 1, 2006·Journal of Neuroscience Methods·D M AlexanderE Gordon
Dec 17, 2014·Frontiers in Human Neuroscience·Róbert BódizsIlona Kovács
Dec 24, 2017·Scientific Reports·Péter P UjmaMartin Dresler
Nov 18, 2020·PLoS Biology·Sofija V Canavan, Daniel Margoliash

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