Quantifying changes in nigrosomes using quantitative susceptibility mapping and neuromelanin imaging for the diagnosis of early-stage Parkinson's disease

The British Journal of Radiology
Hiroto TakahashiNoriyuki Tomiyama

Abstract

To quantify nigral changes with a focus on their spatial variation within the substantia nigra pars compacta (SNpc) for diagnosing early-stage Parkinson's disease (PD). The study participants were 18 patients with early-stage PD (PD group) and 18 healthy controls (HC group) who underwent quantitative susceptibility mapping (QSM) and neuromelanin imaging. The QSM and neuromelanin values in each whole SNpc containing the entire nigrosome and dorsolateral SNpc containing nigrosome 1 were calculated. The neuromelanin area was defined as the volume with a signal-to-noise ratio higher than that of the background region. The significance of intergroup differences in the QSM value and neuromelanin area in each SNpc region was tested. Logit (p) was used to estimate the probability of PD in relation to the QSM value and the neuromelanin area, and receiver operating characteristic analyses were performed for each value. In both SNpc, QSM values were significantly higher and neuromelanin areas were significantly lower in the PD group compared with the HC group (p < 0.05). The respective areas under the receiver operating characteristic curve for the two groups were 0.70/0.73 for the QSM value, 0.81/0.78 for the neuromelanin area in the who...Continue Reading

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Citations

Apr 18, 2019·AJR. American Journal of Roentgenology·Hiroto TakahashiNoriyuki Tomiyama
Dec 18, 2018·Recent Patents on Biotechnology·Feng LinYi Wang
Aug 29, 2020·Brain : a Journal of Neurology·Emma BiondettiStéphane Lehéricy
Aug 28, 2020·Frontiers in Neurology·Germain ArribaratPatrice Péran
Aug 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiangming WangLing Yang
Jun 18, 2020·Frontiers in Neurology·Nadya PyatigorskayaStéphane Lehéricy
Jul 3, 2021·Brain Sciences·Paola FeracoRoberto Monastero

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