Quantifying development: Investigating highly myelinated voxels in preadolescent corpus callosum

NeuroImage
Kirstie J WhitakerCampbell M Clark

Abstract

Multi-echo T(2) relaxation decay data was acquired for 5 preadolescent males (age range 9-12 years). A signal to noise filter appropriate for multi-exponential T(2) analysis was then applied to remove voxels which did not accurately fit the modelled curve. The remaining voxels were designated "highly myelinated" if their myelin water fraction (MWF) was greater than a critical value. We investigated a range of signal to noise filter cut-off values and highly myelinated critical values and demonstrated a significant correlation (r=0.990, p<0.001) between verbal intelligence quotient scores on the Wechsler Intelligence Scale for Children - Revised and myelination of the corpus callosum in children. This relationship is supported by a growing number of studies showing a correlation between white matter development and cognitive ability.

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Citations

Apr 3, 2013·Neurosurgical Focus·Heather S SpaderSean C L Deoni
Feb 18, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Sarah R MorrisCornelia Laule
Apr 21, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Magdalena Babiszewska
Dec 21, 2016·Brain Plasticity·Alex L MacKay, Cornelia Laule
Nov 17, 2020·Frontiers in Human Neuroscience·Christian BeaulieuCornelia Laule

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