Quantifying Direct DNA Damage in the Basal Layer of Skin Exposed to UV Radiation from Sunbeds

Photochemistry and Photobiology
Isla Rose Mary BarnardKenneth Wood

Abstract

Nonmelanoma and melanoma skin cancers are attributable to DNA damage caused by ultraviolet (UV) radiation exposure. One DNA photoproduct, the cyclobutane pyrimidine dimer (CPD), is believed to lead to DNA mutations caused by UV radiation. Using radiative transfer simulations, we compare the number of CPDs directly induced by UV irradiation from artificial and natural UV sources (a standard sunbed and the midday summer Mediterranean sun) for skin types I and II on the Fitzpatrick scale. We use Monte Carlo radiative transfer (MCRT) modeling to track the progression of UV photons through a multilayered three dimensional (3D) grid that simulates the upper layers of the skin. By recording the energy deposited in the DNA-containing cells of the basal layer, the number of CPDs formed can be quantified. The aim of this work was to compare the number of CPDs formed in the basal layer of the skin and by implication the risk of developing cancer, as a consequence of irradiation by artificial and natural sources. Our simulations show that the number of CPDs formed per second during sunbed irradiation is almost three times that formed during solar irradiation.

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Citations

Sep 29, 2019·The British Journal of Dermatology·I R M BarnardR Dawe
Nov 30, 2019·Rapid Communications in Mass Spectrometry : RCM·Amal GuesmiLekha Sleno
May 27, 2020·Photodermatology, Photoimmunology & Photomedicine·Isla Rose Mary BarnardKenneth Wood
Jul 7, 2019·Pharmaceutics·Ye BiLesheng Teng
May 3, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Xiyong HuangXiang Fu
Nov 9, 2020·Lasers in Surgery and Medicine·Lewis McMillanKenneth Wood
Jan 21, 2021·Photochemistry and Photobiology·Ewan EadieKenneth Wood
Jan 20, 2021·Photochemistry and Photobiology·Manuela BuonannoDavid J Brenner
Oct 27, 2021·Photochemistry and Photobiology·Louise FinlaysonKenneth Wood

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