Quantifying discrimination of Framingham risk functions with different survival C statistics.

Statistics in Medicine
Michael PencinaLinye Song

Abstract

Cardiovascular risk prediction functions offer an important diagnostic tool for clinicians and patients themselves. They are usually constructed with the use of parametric or semi-parametric survival regression models. It is essential to be able to evaluate the performance of these models, preferably with summaries that offer natural and intuitive interpretations. The concept of discrimination, popular in the logistic regression context, has been extended to survival analysis. However, the extension is not unique. In this paper, we define discrimination in survival analysis as the model's ability to separate those with longer event-free survival from those with shorter event-free survival within some time horizon of interest. This definition remains consistent with that used in logistic regression, in the sense that it assesses how well the model-based predictions match the observed data. Practical and conceptual examples and numerical simulations are employed to examine four C statistics proposed in the literature to evaluate the performance of survival models. We observe that they differ in the numerical values and aspects of discrimination that they capture. We conclude that the index proposed by Harrell is the most appropri...Continue Reading

References

Sep 1, 1979·American Journal of Epidemiology·W B KannelW P Castelli
Jan 1, 1991·American Heart Journal·K M AndersonW B Kannel
May 1, 1990·Statistics in Medicine·E L Korn, R Simon
Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
May 29, 1998·Circulation·P W WilsonW B Kannel
Sep 4, 1999·Statistics in Medicine·E GrafM Schumacher
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Jul 12, 2002·Statistics in Medicine·Xiao-Hua Zhou, Jaroslaw Harezlak
Mar 1, 1951·American Journal of Public Health and the Nation's Health·T R DAWBERF E MOORE
Feb 26, 2004·Statistics in Medicine·Patrick Royston, Willi Sauerbrei
Mar 2, 2005·Biometrics·Patrick J Heagerty, Yingye Zheng
Oct 13, 2005·Statistics in Medicine·Lloyd E Chambless, Guoqing Diao
May 11, 2007·Biometrics·Ying HuangZiding Feng
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel

❮ Previous
Next ❯

Citations

Jun 10, 2016·International Journal of Endocrinology and Metabolism·Mahnaz BarkhordariMohammadreza Bozorgmanesh
Apr 1, 2014·The Journal of Urology·Aaron D MartinHans G Pohl
Jun 5, 2013·Statistics in Medicine·Audrey MauguenVirginie Rondeau
Oct 7, 2015·Statistics in Medicine·Lili YangSujuan Gao
Apr 1, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Rory Wolfe, John Carlin
Mar 31, 2015·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Camiel L M de Roij van ZuijdewijnMuriel P C Grooteman
Jun 12, 2013·Global Heart·Ralph B D'AgostinoSean Coady
Sep 17, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MichielsF Rotolo
Jan 21, 2017·Resuscitation·Mony ShuvyUNKNOWN Rescu Epistry Investigators
Feb 15, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joshua R LewisRichard L Prince
Oct 21, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Seth T Lirette, Inmaculada Aban
Aug 2, 2017·Journal of the American Heart Association·Joshua R LewisRichard L Prince
May 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Kyunghwa HanByoung Wook Choi
Nov 14, 2018·Journal of Computer Assisted Tomography·Nagina MalguriaElliot K Fishman
Jan 27, 2018·Health Care Management Science·Suiyao ChenMingyang Li
Jan 13, 2019·Journal of Epidemiology and Community Health·Aet SaarKrista Fischer
Sep 29, 2020·Frontiers in Endocrinology·Rikke HjortebjergJan Frystyk
Apr 20, 2017·BMC Medical Research Methodology·M Shafiqur RahmanRumana Z Omar
May 17, 2019·Diagnostic and Prognostic Research·Nancy R Cook
Aug 27, 2019·Journal of the American Heart Association·Takuya NagataToshiharu Ninomiya
May 22, 2020·Pharmaceutical Statistics·Samantha-Jo Caetano, Gregory Pond
Nov 10, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Hye-Sung SoJong-Seon Park
Oct 28, 2019·The American Journal of Surgical Pathology·Margaret L Compton, Justin M M Cates

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.