Quantifying epileptogenesis in rats with spontaneous and responsive brain state dynamics

Brain Communications
Dakota N CrispWilliam C Stacey

Abstract

There is a crucial need to identify biomarkers of epileptogenesis that will help predict later development of seizures. This work identifies two novel electrophysiological biomarkers that quantify epilepsy progression in a rat model of epileptogenesis. The long-term tetanus toxin rat model was used to show the development and remission of epilepsy over several weeks. We measured the response to periodic electrical stimulation and features of spontaneous seizure dynamics over several weeks. Both biomarkers showed dramatic changes during epileptogenesis. Electrically induced responses began to change several days before seizures began and continued to change until seizures resolved. These changes were consistent across animals and allowed development of an algorithm that could differentiate which animals would later develop epilepsy. Once seizures began, there was a progression of seizure dynamics that closely follows recent theoretical predictions, suggesting that the underlying brain state was changing over time. This research demonstrates that induced electrical responses and seizure onset dynamics are useful biomarkers to quantify dynamical changes in epileptogenesis. These tools hold promise for robust quantification of the ...Continue Reading

References

Apr 1, 1986·Physical Review A: General Physics·P Bryant, K Wiesenfeld
Feb 28, 1994·Physical Review Letters·S T VohraK Wiesenfeld
Nov 13, 2002·Neurology·Susan T Herman
Dec 18, 2003·Supplements to Clinical Neurophysiology·Vahe E Amassian, Mark Stewart
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gonzalo Alarcón
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S KalitzinF Lopes da Silva
Dec 27, 2005·Epilepsy Research·Susan T Herman
Mar 3, 2009·Brain : a Journal of Neurology·Radwa BadawySamuel Berkovic
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shilpa D KadamF Edward Dudek
Nov 10, 2010·Frontiers in Systems Neuroscience·Olivier DavidPhilippe Kahane
Dec 7, 2011·Epilepsy & Behavior : E&B·Dean R FreestoneMark J Cook
Jan 1, 2013·International Journal of Neural Systems·Radwa A B BadawyRichard A L Macdonell
May 21, 2013·Annals of Neurology·Radwa A B BadawyMark J Cook
Nov 2, 2013·Brain : a Journal of Neurology·Piero PeruccaJean Gotman
Feb 21, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Asla Pitkänen, Riikka Immonen
Feb 26, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katarzyna Lukasiuk, Albert J Becker
Jun 13, 2014·Brain : a Journal of Neurology·Viktor K JirsaChristophe Bernard
Sep 20, 2015·Cold Spring Harbor Perspectives in Medicine·Asla PitkänenKevin J Staley
Jan 26, 2016·IEEE Transactions on Signal Processing : a Publication of the IEEE Signal Processing Society·Visar BerishaAndreas Spanias
Jan 1, 2015·IEEE Journal of Translational Engineering in Health and Medicine·Kyle D SlaterUNKNOWN Bionic Vision Australia Consortium
Jun 23, 2016·Epilepsy Currents·Cara LongRay Dingledine
Mar 24, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dan Z MilikovskyAlon Friedman
Jul 27, 2017·Journal of Mathematical Neuroscience·Maria Luisa SaggioViktor K Jirsa
Aug 29, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fatemeh BahariBruce J Gluckman
Oct 12, 2018·Neurobiology of Disease·Hiram Luna-MunguiaWilliam C Stacey

❮ Previous
Next ❯

Citations

Jul 22, 2020·ELife·Maria Luisa SaggioWilliam C Stacey
Jun 1, 2021·Frontiers in Neurology·William J BoslTobias Loddenkemper

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

Deep Blue Library
neuroBi
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Pharmacology
Yuka KasaharaRyuta Koyama
Seminars in Fetal & Neonatal Medicine
Anna-Maria KatsarouSolomon L Moshé
Cold Spring Harbor Perspectives in Medicine
Asla PitkänenKevin J Staley
© 2021 Meta ULC. All rights reserved