Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly-L-lysine and a starburst dendrimer

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Michael T McMahonPeter C M van Zijl

Abstract

The ability to measure proton exchange rates in tissue using MRI would be very useful for quantitative assessment of magnetization transfer properties, both in conventional MT imaging and in the more recent chemical exchange saturation transfer (CEST) approach. CEST is a new MR contrast mechanism that depends on several factors, including the exchange rate of labile protons in the agent in a pH-dependent manner. Two new methods to monitor local exchange rate based on CEST are introduced. The two MRI-compatible approaches to measure exchange are quantifying exchange using saturation time (QUEST) dependence and quantifying exchange using saturation power (QUESP) dependence. These techniques were applied to poly-L-lysine (PLL) and a generation-5 polyamidoamine dendrimer (SPD-5) to measure the pH dependence of amide proton exchange rates in the physiologic range. Data were fit both to an analytical expression and to numerical solutions to the Bloch equations. Results were validated by comparison with exchange rates determined by two established spectroscopic methods. The exchange rates determined using the four methods were pooled for the pH-calibration curve of the agents consisting of contributions from spontaneous (k0) acid cata...Continue Reading

References

Nov 1, 1992·Journal of Biomolecular NMR·M PiottoV Sklenár
Jun 14, 1970·Journal of Molecular Biology·B McConnell, P H von Hippel
Nov 1, 1983·Quarterly Reviews of Biophysics·S W Englander, N R Kallenbach
Feb 15, 1983·Biochemistry·R B GregoryA Rosenberg
Sep 1, 1993·Proteins·Y BaiS W Englander
Jan 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E Liepinsh, G Otting
Nov 14, 1997·Journal of Magnetic Resonance·E Baguet, C Roby
Jul 9, 1998·Journal of Magnetic Resonance·V Guivel-ScharenR S Balaban
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S MoriP C van Zijl
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P B Kingsley, W G Monahan
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M Ward, R S Balaban
Aug 30, 2001·Journal of the American Chemical Society·N GoffeneyP C van Zijl
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Silvio AimeEnzo Terreno
Nov 16, 2002·Angewandte Chemie·Silvio AimeEnzo Terreno
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter C M van ZijlSusumu Mori
May 28, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karim SnoussiPeter C M van Zijl
Oct 22, 2003·Accounts of Chemical Research·Shanrong ZhangA Dean Sherry
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M van Zijl
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M Van Zijl
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Silvio AimeEnzo Terreno
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Donald E WoessnerA Dean Sherry
May 17, 2005·Journal of Magnetic Resonance·Phillip Zhe SunJinyuan Zhou

❮ Previous
Next ❯

Citations

Mar 9, 2007·Neuroradiology·Letterio S Politi
Mar 7, 2009·Accounts of Chemical Research·Luis M De Leon-RodriguezA Dean Sherry
Apr 20, 2010·Chemical Reviews·Subha ViswanathanA Dean Sherry
Jan 8, 2013·Journal of the American Chemical Society·Amnon Bar-ShirAssaf A Gilad
Mar 26, 2008·Journal of the American Chemical Society·Jason M ZhaoPeter C M van Zijl
Jan 30, 2007·Nature Biotechnology·Assaf A GiladPeter C M van Zijl
Sep 18, 2010·Organic & Biomolecular Chemistry·Yunkou WuMark Woods
Jul 24, 2008·Annual Review of Biomedical Engineering·A Dean Sherry, Mark Woods
Mar 19, 2014·PloS One·Naira P Martínez VeraStefan Ropele
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peter C M van ZijlA Dean Sherry
Aug 3, 2011·Journal of Biomolecular NMR·Carolyn B LauzonJames T Stivers
Feb 27, 2014·Magma·Anja Müller-LutzHans-Jörg Wittsack
Dec 18, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaolei SongMichael T McMahon
Jul 15, 2015·Contrast Media & Molecular Imaging·Jae-Seung LeeRavinder R Regatte
Feb 26, 2016·Nano Letters·Wojciech G LesniakMichael T McMahon
Dec 23, 2015·Contrast Media & Molecular Imaging·Phillip Zhe SunRenhua Wu
Sep 29, 2015·NMR in Biomedicine·Felizitas C WermterWolfgang Dreher
Feb 4, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Assaf A GiladJeff W M Bulte
Oct 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jimin RenA Dean Sherry
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M van Zijl
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guanshu LiuMark D Pagel
Dec 20, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elizabeth A LouieBruce M Damon
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Phillip Zhe SunA Gregory Sorensen
Sep 16, 2008·NMR in Biomedicine·K GlundeZ M Bhujwalla
Jul 31, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Phillip Zhe Sun, A Gregory Sorensen
Oct 18, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kannie W Y ChanPeter C M van Zijl
Jan 15, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y K TeeM A Chappell
Jan 17, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaolei SongMichael T McMahon
Sep 28, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Phillip Zhe SunA Gregory Sorensen
Jul 28, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nirbhay N YadavPeter C M van Zijl
Nov 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Craig K JonesPeter C M van Zijl
Mar 7, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guanshu LiuMichael T McMahon
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zhongliang ZuDaniel F Gochberg
Jun 27, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nirbhay N YadavPeter C M van Zijl
Feb 14, 2013·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Adrienne N DulaJohn C Gore
Jan 11, 2013·NMR in Biomedicine·Guanshu LiuMichael T McMahon
Oct 16, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dario Livio LongoSilvio Aime
Mar 12, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xuna ZhaoJinyuan Zhou
May 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rachel ScheideggerDavid C Alsop
Apr 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tao JinSeong-Gi Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Peter C M van ZijlA Dean Sherry
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Donald E WoessnerA Dean Sherry
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Jinyuan ZhouPeter C M van Zijl
© 2021 Meta ULC. All rights reserved