Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.

Cerebral Cortex
Madhura BaxiYogesh Rathi

Abstract

Early neuroimaging work in twin studies focused on studying genetic and environmental influence on gray matter macrostructure. However, it is also important to understand how gray matter microstructure is influenced by genes and environment to facilitate future investigations of their influence in mental disorders. Advanced diffusion MRI (dMRI) measures allow more accurate assessment of gray matter microstructure compared with conventional diffusion tensor measures. To understand genetic and environmental influence on gray matter, we used diffusion and structural MRI data from a large twin and sibling study (N = 840) and computed advanced dMRI measures including return to origin probability (RTOP), which is heavily weighted toward intracellular and intra-axonal restricted spaces, and mean squared displacement (MSD), more heavily weighted to diffusion in extracellular space and large cell bodies in gray matter. We show that while macrostructural features like brain volume are mainly genetically influenced, RTOP and MSD can together tap into both genetic and environmental influence on microstructure.

References

Jul 8, 1988·Science·P Rakic
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Feb 1, 1997·Brain : a Journal of Neurology·A J BartleyD R Weinberger
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·W R ShankleJ Hara
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Apr 9, 1999·NMR in Biomedicine·R V MulkernS E Maier
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Nov 6, 2001·Nature Neuroscience·P M ThompsonA W Toga
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y AssafY Cohen
Oct 9, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arthur F KramerWilliam T Greenough
Feb 3, 2005·The Journal of Ambulatory Care Management·MaryAnn Sorensen Allacci
Sep 6, 2005·Environmental Health Perspectives·Philip J LandriganDaniel Droller
Oct 20, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Patric HagmannReto Meuli
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael C OldhamDaniel H Geschwind
Apr 7, 2007·Human Brain Mapping·Jiska S PeperHilleke E Hulshoff Pol
Oct 2, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·J Eric SchmittMichael C Neale
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip ShawSteve P Wise
May 23, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·George PengasPeter J Nestor
Feb 18, 2010·The Psychiatric Clinics of North America·Pablo V GejmanJubao Duan
Feb 24, 2010·NeuroImage·Jeffrey RogersDavid C Glahn
Apr 7, 2010·Neurobiology of Aging·William S KremenAnders M Dale
Jul 16, 2010·NMR in Biomedicine·Jens H Jensen, Joseph A Helpern
Oct 5, 2010·NMR in Biomedicine·Derek K Jones, Mara Cercignani
Oct 5, 2010·Frontiers in Aging Neuroscience·Michelle W VossArthur F Kramer
Nov 4, 2010·Journal of Geriatric Psychiatry and Neurology·Lynn M BekrisDebby W Tsuang
Jan 15, 2011·Neuroreport·Anand A JoshiPaul M Thompson
Mar 26, 2011·Neurosurgery Clinics of North America·Lauren J O'Donnell, Carl-Fredrik Westin
Aug 22, 2012·Cold Spring Harbor Perspectives in Medicine·Dennis W Dickson
Sep 27, 2012·Metabolism: Clinical and Experimental·Bruce S McEwen, Linn Getz
Jan 19, 2013·Nature Reviews. Genetics·Albert Tenesa, Chris S Haley
Feb 19, 2013·Trends in Neurosciences·Karl ZillesKatrin Amunts
Mar 9, 2013·Current Drug Targets·Grazyna Rajkowska, Craig A Stockmeier
May 15, 2013·NeuroImage·Matthew F GlasserUNKNOWN WU-Minn HCP Consortium
May 21, 2013·NeuroImage·David C Van EssenUNKNOWN WU-Minn HCP Consortium
May 25, 2013·NeuroImage·Kamil UğurbilUNKNOWN WU-Minn HCP Consortium
May 25, 2013·NeuroImage·Stamatios N SotiropoulosUNKNOWN WU-Minn HCP Consortium

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Citations

Apr 8, 2021·Brain Imaging and Behavior·Ryan P CabeenJohn M Allman

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