Quantifying Global Drivers of Zoonotic Bat Viruses: A Process-Based Perspective

The American Naturalist
Liam BrierleyKate E Jones

Abstract

Emerging infectious diseases (EIDs), particularly zoonoses, represent a significant threat to global health. Emergence is often driven by anthropogenic activity (e.g., travel, land use change). Although disease emergence frameworks suggest multiple steps from initial zoonotic transmission to human-to-human spread, there have been few attempts to empirically model specific steps. We create a process-based framework to separate out components of individual emergence steps. We focus on early emergence and expand the first step, zoonotic transmission, into processes of generation of pathogen richness, transmission opportunity, and establishment, each with its own hypothesized drivers. Using this structure, we build a spatial empirical model of these drivers, taking bat viruses shared with humans as a case study. We show that drivers of both viral richness (host diversity and climatic variability) and transmission opportunity (human population density, bushmeat hunting, and livestock production) are associated with virus sharing between humans and bats. We also show spatial heterogeneity between the global patterns of these two processes, suggesting that high-priority locations for pathogen discovery and surveillance in wildlife may...Continue Reading

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Citations

Jun 19, 2016·Trends in Parasitology·Barbara A HanJohn M Drake
Jul 31, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Clifton D McKeeColleen T Webb
May 31, 2017·Nature Reviews. Microbiology·Raina K PlowrightJames O Lloyd-Smith
Jun 22, 2017·Nature·Kevin J OlivalPeter Daszak
Oct 17, 2017·EcoHealth·Quinn M R WebberCraig K R Willis
Dec 20, 2019·The Journal of Animal Ecology·Daniel J BeckerRaina K Plowright
Jul 2, 2020·Ecology and Evolution·Cylita GuyNicole Mideo
Apr 13, 2019·Tropical Medicine and Infectious Disease·Kavita M BergerDavid T S Hayman
Aug 14, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alex D WashburneRaina K Plowright
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·Efstathios S Giotis
Jun 7, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I ScoonesJ L N Wood
Jan 30, 2018·Frontiers in Immunology·Caroline K GliddenAnna Jolles
Oct 27, 2017·Nature Communications·Toph AllenPeter Daszak
Jan 16, 2019·Microbiology Resource Announcements·Luciano Chaves Franco FilhoMarcio Roberto Teixeira Nunes
Dec 1, 2020·PLoS Pathogens·Feifei ZhangMark E J Woolhouse
Dec 10, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Audrey LacroixPhilippe Buchy
Jun 17, 2020·Biological Conservation·Douglas MacFarlane, Ricardo Rocha
Apr 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Felicia Keesing, Richard S Ostfeld
May 19, 2021·Integrative Zoology·Leidy Azucena Ramírez-FráncelGiovany Guevara
Aug 11, 2021·Proceedings. Biological Sciences·Elisa VisherMichael Boots

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