Quantifying Hemodynamic Changes in Moyamoya Disease Based on Two-Dimensional Cine Phase-Contrast Magnetic Resonance Imaging and Computational Fluid Dynamics

World Neurosurgery
Wenbo SunHaibo Xu

Abstract

To investigate hemodynamic changes in moyamoya disease (MMD) via two-dimensional cine phase-contrast magnetic resonance imaging and computational fluid dynamics. In 18 patients with MMD and 10 healthy control subjects, phase-contrast magnetic resonance imaging was performed to quantify flow rate of main supplying arteries, including internal carotid arteries (ICAs) and vertebral arteries. Mean flow rate in these vessels was adopted as the patient-specific boundary condition for computational fluid dynamics simulation of the circle of Willis in MMD and control groups. Pressure drop in both ICAs and their difference, wall shear stress and secondary flow in the carotid siphon of ICAs, and flow rate and size of posterior communicating arteries (PComAs) were compared between MMD and control groups. Four patients with MMD underwent follow-up scans for longitudinal comparison. Phase-contrast magnetic resonance imaging data revealed significantly different flow rate in the left ICA and right vertebral arteries between MMD and control groups. Computational fluid dynamics simulation demonstrated similar wall shear stress and similar secondary flow of both ICAs but significantly higher pressure drop in left ICA, higher pressure drop diffe...Continue Reading

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