Quantifying maternally derived respiratory syncytial virus specific neutralising antibodies in a birth cohort from coastal Kenya

Vaccine
Joyce U NyiroD J Nokes

Abstract

Severe respiratory syncytial virus (RSV) disease occurs predominantly in children under 6 months of age. There is no licensed RSV vaccine. Protection of young infants could be achieved by a maternal vaccine to boost titres of passively transferred protective antibodies. Data on the level and kinetics of functional RSV-specific antibody at birth and over the early infant period would inform vaccine product design. From a birth cohort study (2002-2007) in Kilifi, Kenya, 100 participants were randomly selected for whom cord blood and 2 subsequent 3-monthly blood samples within the first year of life, were available. RSV antibodies against the A2 strain of RSV were assayed and recorded as the logarithm (base 2) plaque reduction neutralisation test (PRNT) titre. Analysis by linear regression accounted for within-person clustering. The geometric mean neutralisation antibody titre was 10.6 (SD: 1.13) at birth with a log-linear decay over the first 6 months of life. The estimated rate of decay was -0.58 (SD: 0.20) log2PRNT titre per month and a half-life of 36 days. There was no significant interaction between cord titre and rate of decay with age. Mean cord titres rose and fell in a pattern temporally tracking community virus transmis...Continue Reading

References

Aug 26, 1998·Vaccine·J EnglundP A Piedra
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D James NokesGraham F Medley
Oct 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D James NokesGraham F Medley
May 27, 2010·JAMA : the Journal of the American Medical Association·James A BerkleyD James Nokes
May 1, 2012·International Journal of Epidemiology·J Anthony G ScottThomas N Williams
Jun 7, 2014·The Journal of Infectious Diseases·Helen Y ChuJanet A Englund

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Citations

Dec 5, 2015·Expert Review of Vaccines·Simon B DrysdaleAndrew J Pollard
Feb 23, 2017·Annual Review of Immunology·Peter J M OpenshawCecilia Johansson
May 21, 2017·Expert Review of Vaccines·Tonya VillafanaMark T Esser
Aug 14, 2019·The Pediatric Infectious Disease Journal·Jessica E AtwellRuth A Karron
Feb 16, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Mehmet YildizAyper Somer

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Clinical Trials Mentioned

NCT01905215

Software Mentioned

STATA

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