Quantifying medial temporal lobe damage in memory-impaired patients

Hippocampus
Jeffrey J Gold, L R Squire

Abstract

Studies of memory-impaired patients will be most useful when quantitative neuroanatomical information is available about the patients being studied. Toward that end, in the case of medial temporal lobe amnesia, protocols have been developed from histological material that identify the boundaries of relevant structures on magnetic resonance images. Because the size of these structures varies considerably in the normal population, some correction for overall brain size is usually employed when calculating volume measurements. Although different correction procedures have been used to normalize for brain size, there has been little study of how well different methods reduce variability and which methods might be most useful. We measured the volume of the hippocampal region (hippocampus proper, dentate gyrus, and subicular complex) and the volumes of the temporopolar, entorhinal, perirhinal, and parahippocampal cortices in five memory-impaired patients and 30 controls. We then compared three different methods for normalizing the volume measurements: normalization by intracranial volume, normalization by aligning the brain to a standard atlas, and normalization by brain area at the level of the anterior commissure. Normalization by ...Continue Reading

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Citations

Feb 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·C Brock KirwanLarry R Squire
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·C Brock KirwanLarry R Squire
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Larry R SquireKristin N Mauldin
May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhuang SongLarry R Squire
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ashley R KnutsonLarry R Squire
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Adam J O DedeLarry R Squire
May 30, 2009·Chemical Senses·Naomi J Goodrich-HunsakerRamona O Hopkins
Sep 19, 2006·Learning & Memory·Jeffrey J GoldLarry R Squire
Nov 13, 2004·Learning & Memory·Daniel A LevyLarry R Squire
Nov 17, 2007·Journal of Cognitive Neuroscience·P J BayleyL R Squire
Feb 29, 2008·Journal of Cognitive Neuroscience·R Shayna RosenbaumBrian Levine
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yael ShragerLarry R Squire
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine Smith, Larry R Squire
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annette JenesonLarry R Squire
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine N SmithLarry R Squire
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J BayleyLarry R Squire
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine N Smith, Larry R Squire
Feb 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yael ShragerLarry R Squire
Apr 20, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sinéad L MullallyEleanor A Maguire
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Soyun KimLarry R Squire
Mar 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annette JenesonLarry R Squire
Jan 28, 2014·Journal of the International Neuropsychological Society : JINS·Lily RiggsDonald J Mabbott
Feb 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Soyun KimLarry R Squire
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christine N SmithLarry R Squire
Apr 9, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Heather B EnglandBenjamin M Hampstead
Jun 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey J GoldLarry R Squire
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yael ShragerLarry R Squire
Apr 5, 2011·Annual Review of Neuroscience·Larry R Squire, John T Wixted
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Justin S FeinsteinDaniel Tranel
May 26, 2005·Cognitive, Affective & Behavioral Neuroscience·M A ConroyL R Squire
Nov 6, 2013·Pediatric Neurology·Jeffrey J Gold, Doris A Trauner
Oct 8, 2013·Clinics in Geriatric Medicine·Benjamin M Hampstead, Gregory S Brown
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Soyun KimLarry R Squire
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Jul 25, 2013·The Journal of Comparative Neurology·Melissa C DuffDaniel Tranel
Jun 1, 2005·Neuron·Peter J BayleyLarry R Squire

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