Quantifying Microvascular Changes Using OCT Angiography in Diabetic Eyes without Clinical Evidence of Retinopathy

Ophthalmology Retina
A Yasin AlibhaiNadia K Waheed

Abstract

To compare quantitative OCT angiography (OCTA) parameters of macular ischemia in diabetic eyes without retinopathy with those in healthy nondiabetic controls. Cross-sectional study from August 2014 through June 2017. Thirty-nine eyes of 39 diabetic patients without clinical evidence of diabetic retinopathy and 40 eyes of 40 healthy nondiabetic subjects. Subjects underwent OCTA imaging using prototype AngioVue software (RTVue XR Avanti). Analyses of the foveal avascular zone (FAZ) and vasculature surrounding the FAZ were performed on the automatically generated en face OCTA images of the superficial and deep retinal vasculatures using vessel-based and FAZ-based metrics. Comparison of measurements made in the superficial and deep retinal capillary plexuses of diabetic eyes and normal eyes. FAZ-based analysis revealed statistically significant differences between diabetic and normal eyes in FAZ area (superficial and deep layers), perimeter (superficial layer), major axis length (superficial layer), and minor axis layer (superficial and deep layers). Vessel-based analysis revealed statistically significant differences in the binarized flow index (superficial and deep layers), both including and excluding the FAZ area. Quantitative ...Continue Reading

Citations

Sep 2, 2019·Current Diabetes Reports·Changyow C Kwan, Amani A Fawzi
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Sep 1, 2020·Investigative Ophthalmology & Visual Science·Rachel E LindermanJoseph Carroll
Dec 5, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Phillip Bedggood, Andrew Metha
Nov 12, 2019·Schizophrenia Research·Steven M SilversteinDocia L Demmin
Dec 10, 2020·International Journal of Retina and Vitreous·Eugenia Custo GreigNadia K Waheed
Dec 22, 2020·Translational Vision Science & Technology·Ylenia GiarratanoMiguel O Bernabeu
Mar 25, 2021·Current Eye Research·Tuna Celik BuyuktepeEmin Özmert
Jul 27, 2021·Ophthalmic Surgery, Lasers & Imaging Retina·Anna N StulovaDmitry V Lipatov

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