Quantifying Postural Control in Premanifest and Manifest Huntington Disease Using Wearable Sensors.

Neurorehabilitation and Neural Repair
Franchino PorciunculaAshwini K Rao

Abstract

Background. Impairments in postural control in Huntington disease (HD) have important consequences for daily functioning. This observational study systematically examined baseline postural control and the effect of sensory attenuation and sensory enhancement on postural control across the spectrum of HD. Methods. Participants (n = 39) included healthy controls and individuals in premanifest (pHD) and manifest stages (mHD) of HD. Using wearable sensors, postural control was assessed according to (1) postural set (sit vs stand), (2) sensory attenuation using clinical test of sensory integration, and (3) sensory enhancement with gaze fixation. Outcomes included sway smoothness, amplitude, and frequency. Results. Based on postural set, pHD reduced postural sway in sitting relative to standing, whereas mHD had pronounced sway in standing and sitting, highlighting a baseline postural deficit. During sensory attenuation, postural control in pHD deteriorated relative to controls when proprioceptive demands were high (eyes closed on foam), whereas mHD had significant deterioration of postural control when proprioception was attenuated (eyes open and closed on foam). Finally, gaze fixation improved sway smoothness, amplitude, and frequen...Continue Reading

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Citations

Aug 14, 2021·Frontiers in Bioengineering and Biotechnology·Lauren S Talman, Amie L Hiller

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Software Mentioned

Power
SPSS
Mobility
MATLAB
mCTSIB
pHD

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