Quantifying the benefit of a proteome reserve in fluctuating environments

Nature Communications
Matteo MoriTerence Hwa

Abstract

The overexpression of proteins is a major burden for fast-growing bacteria. Paradoxically, recent characterization of the proteome of Escherichia coli found many proteins expressed in excess of what appears to be optimal for exponential growth. Here, we quantitatively investigate the possibility that this overexpression constitutes a strategic reserve kept by starving cells to quickly meet demand upon sudden improvement in growth conditions. For cells exposed to repeated famine-and-feast cycles, we derive a simple relation between the duration of feast and the allocation of the ribosomal protein reserve to maximize the overall gain in biomass during the feast.

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Citations

Oct 12, 2019·FEMS Yeast Research·Rosemary Yu, Jens Nielsen
Sep 26, 2019·Cellular and Molecular Life Sciences : CMLS·Manlu Zhu, Xiongfeng Dai
Mar 4, 2020·Journal of Bacteriology·Heather A FeagaJonathan Dworkin
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Bin NiVictor Sourjik
May 10, 2019·NPJ Systems Biology and Applications·Matteo MoriAndrea De Martino
Feb 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yinon M Bar-On, Ron Milo
Mar 6, 2019·Molecular Biology and Evolution·Philippe RemigiPaul B Rainey
Dec 15, 2020·Journal of Biotechnology·Pranas GrigaitisNadine Veith
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Mar 10, 2021·NPJ Systems Biology and Applications·Francis MairetHidde de Jong
May 26, 2020·Trends in Biochemical Sciences·Xiongfeng Dai, Manlu Zhu
Mar 26, 2021·Molecular Systems Biology·Emma J ChoryKevin M Esvelt
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Jun 18, 2021·Nature Communications·Jen NguyenRoman Stocker
Aug 7, 2021·Scientific Reports·Esther M SundermannDavid Heckmann
Oct 20, 2021·The FEBS Journal·Diana SerbanescuShiladitya Banerjee

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