Quantifying the correlation between photoplethysmography and laser Doppler flowmetry microvascular low-frequency oscillations

Journal of Biomedical Optics
Irina MizevaJohn Allen

Abstract

Photoplethysmography (PPG) and laser Doppler flowmetry (LDF) are two recognized optical techniques that can track low-frequency perfusion changes in microcirculation. The aim of this study was to determine, in healthy subjects, the correlation between the techniques for specific low-frequency bands previously defined for microcirculation. Twelve healthy male subjects (age range 18 to 50 years) were studied, with PPG and LDF signals recorded for 20 min from their right and left index (PPG) and middle (LDF) fingers. Wavelet analysis comprised dividing the low-frequency integral wavelet spectrum (IWS) into five established physiological bands relating to cardiac, respiratory, myogenic, neurogenic, and endothelial activities. The correlation between PPG and LDF was quantified using wavelet correlation analysis and Spearman correlation analysis of the median IWS amplitude. The median wavelet correlation between signals (right-left side average) was 0.45 (cardiac), 0.49 (respiratory), 0.86 (myogenic), 0.91 (neurogenic), and 0.91 (endothelial). The correlation of IWS amplitude values (right-left side average) was statistically significant for the cardiac (ρ = 0.64, p < 0.05) and endothelial (ρ = 0.62, p < 0.05) bands. This pilot study...Continue Reading

Citations

Sep 13, 2017·Journal of Biomedical Optics·C Ikenna NwaforJeffrey E Thatcher
Mar 20, 2020·Journal of Applied Physiology·Luis Monteiro RodriguesHenrique N Silva
Mar 7, 2021·Sensors·Zbignevs MarcinkevicsAndris Grabovskis
Jun 5, 2021·Biophysical Journal·Anatoly S KaravaevAnton R Kiselev
Nov 4, 2021·Scientific Reports·Simon Mylius RasmussenLars Peter Schousboe

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