Quantifying the economic cost of antibiotic resistance and the impact of related interventions: rapid methodological review, conceptual framework and recommendations for future studies

BMC Medicine
Mark JitKoen B Pouwels

Abstract

Antibiotic resistance (ABR) poses a major threat to health and economic wellbeing worldwide. Reducing ABR will require government interventions to incentivise antibiotic development, prudent antibiotic use, infection control and deployment of partial substitutes such as rapid diagnostics and vaccines. The scale of such interventions needs to be calibrated to accurate and comprehensive estimates of the economic cost of ABR. A conceptual framework for estimating costs attributable to ABR was developed based on previous literature highlighting methodological shortcomings in the field and additional deductive epidemiological and economic reasoning. The framework was supplemented by a rapid methodological review. The review identified 110 articles quantifying ABR costs. Most were based in high-income countries only (91/110), set in hospitals (95/110), used a healthcare provider or payer perspective (97/110), and used matched cohort approaches to compare costs of patients with antibiotic-resistant infections and antibiotic-susceptible infections (or no infection) (87/110). Better use of methods to correct biases and confounding when making this comparison is needed. Findings also need to be extended beyond their limitations in (1) ti...Continue Reading

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Citations

Jan 28, 2021·Trends in Microbiology·Ana Carolina Maganha de Almeida KumlienJosé Luis Balcázar
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ana Marta-CostaPatrícia Poeta
Jun 10, 2021·Human Vaccines & Immunotherapeutics·NorAziyah Mat RahimSazaly AbuBakar
Aug 10, 2021·Health Economics Review·F AntoñanzasR Rodríguez-Ibeas

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