Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches

Scientific Reports
Kevin LitchfieldClare Turnbull

Abstract

A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to be explained by heritable factors. Recent genome-wide association studies (GWAS) have successfully identified a number of common SNPs associated with TGCT. It is however, unclear how much common variation there is left to be accounted for by other, yet to be identified, common SNPs and what contribution common genetic variation makes to the heritable risk of TGCT. We approached this question using two complimentary analytical techniques. We undertook a population-based analysis of the Swedish family-cancer database, through which we estimated that the heritability of TGCT at 48.9% (CI:47.2%-52.3%). We also applied Genome-Wide Complex Trait Analysis to 922 cases and 4,842 controls to estimate the heritability of TGCT. The heritability explained by known common risk SNPs identified by GWAS was 9.1%, whereas the heritability explained by all common SNPs was 37.4% (CI:27.6%-47.2%). These complementary findings indicate that the known TGCT SNPs only explain a small proportion of the heritability and many additional common SNPs remain to be identified. The data also suggests that a fraction of the heritability of TGCT is likely to be explained by other class...Continue Reading

References

Oct 13, 2006·Nature Clinical Practice. Urology·Freddie BrayHenrik Møller
Apr 19, 2008·Molecular and Cellular Endocrinology·David Møbjerg KristensenEwa Rajpert-De Meyts
Jun 2, 2009·Nature Genetics·Elizabeth A RapleyMichael R Stratton
Jun 2, 2009·Nature Genetics·Peter A KanetskyKatherine L Nathanson
Jul 31, 2009·International Journal of Cancer. Journal International Du Cancer·Kari HemminkiJan Sundquist
Nov 12, 2009·Future Oncology·Katherine A McGlynn, Michael B Cook
Jun 15, 2010·Nature Genetics·Clare TurnbullUNKNOWN UK Testicular Cancer Collaboration
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
May 10, 2011·Human Molecular Genetics·Peter A KanetskyKatherine L Nathanson
May 10, 2011·Nature Genetics·Jian YangPeter M Visscher
Aug 19, 2011·British Journal of Cancer·D M McElvennyD Coggon
Feb 5, 2013·Nature·Joshua S BloomLeonid Kruglyak
Mar 7, 2013·Human Molecular Genetics·Fredrick R SchumacherKatherine A McGlynn
Mar 29, 2013·Nature Genetics·Kyriaki MichailidouDouglas F Easton
Mar 29, 2013·Nature Genetics·Paul D P PharoahThomas A Sellers
May 15, 2013·Nature Genetics·Charles C ChungKatherine L Nathanson
Jun 13, 2013·Methods in Molecular Biology·Jian YangPeter M Visscher
Dec 29, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Charlotte Le CornetFreddie Bray
Jun 20, 2014·Human Molecular Genetics·Yi LuStuart Macgregor
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·David GolanSaharon Rosset

❮ Previous
Next ❯

Citations

Oct 16, 2015·British Journal of Cancer·Kevin LitchfieldClare Turnbull
Jun 15, 2016·Nature Reviews. Urology·Kevin LitchfieldClare Turnbull
Dec 21, 2016·Nature Communications·Kevin LitchfieldClare Turnbull
Jul 14, 2018·Current Opinion in Urology·Solomon L Woldu, Aditya Bagrodia
Jan 25, 2019·JAMA Oncology·Saud H AlDubayanUNKNOWN Regeneron Genetics Center (RGC) Research Team
Mar 22, 2019·Andrology·J T LafinJ F Amatruda
Oct 28, 2015·Nature Communications·Kevin LitchfieldClare Turnbull
Jul 17, 2019·Andrology·C LovedayC Turnbull
Sep 2, 2016·Current Opinion in Urology·Solomon L WolduAditya Bagrodia
May 28, 2019·Genetics·Eugenio López-Cortegano, Armando Caballero
Mar 22, 2018·Oncotarget·Chey LovedayClare Turnbull
May 16, 2018·International Journal of Cancer. Journal International Du Cancer·Beatriz Paumard-HernándezJavier Benítez
Jun 23, 2020·Seminars in Cancer Biology·Viola FanfaniGiovanni Stracquadanio
Apr 30, 2021·Development·Nicholas J WebsterJason D Heaney
Jul 1, 2019·Genetics·Eugenio López-Cortegano, Armando Caballero
Mar 19, 2021·Cancer Research·Viola FanfaniGiovanni Stracquadanio
Aug 17, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F HoneckerA Horwich
Jul 25, 2021·Nature Communications·John PlutaUNKNOWN Testicular Cancer Consortium

❮ Previous
Next ❯

Software Mentioned

GCTA
kinship2
DMU
R
MCMCglmm
PLINK
coda

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.