Quantifying the material and structural determinants of bone strength

Best Practice & Research. Clinical Rheumatology
Mary L Bouxsein, Ego Seeman

Abstract

The ability of a bone to resist fracture depends on the amount of bone present, the spatial distribution of the bone mass as cortical and trabecular bone and the intrinsic properties of the bone material. Whereas low areal bone mineral density (aBMD) predicts fractures, its sensitivity and specificity is low, as over 50% of fractures occur in persons without osteoporosis by BMD testing and most women with osteoporosis do not sustain a fracture. New non-invasive imaging techniques, including three-dimensional (3D) assessments of bone density and geometry, microarchitecture and integrated measurements of bone strength such as finite element analysis (FEA), provide estimates of bone strength that can be used to increase the sensitivity and specificity of fracture risk assessment. Initial observations have shown that these techniques provide information that will improve our understanding of the pathophysiology of skeletal fragility and suggest that these techniques are likely to have a role in the clinical management of individuals at risk for fracture.

References

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D R CarterR Marcus
Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G BoivinP J Meunier
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S MajumdarH Genant
May 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S GramppM Chavez
Jan 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S MajumdarA Mathur
Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T M LinkH K Genant
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y WuJ L Ackerman
Mar 2, 1999·Journal of Computer Assisted Tomography·T F LangH K Genant
Sep 7, 1999·Journal of Biomechanics·D D CodyD P Fyhrie
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S MajumdarH K Genant
Dec 22, 1999·European Radiology·T M LinkJ E Adams
Oct 12, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A NelsonT J Beck
May 9, 2001·Journal of Biomechanical Engineering·W PistoiaP Rüegsegger
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T J BeckS R Cummings
Jul 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A C LookerE S Orwoll
Aug 14, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F W WehrliP J Snyder
Nov 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T J BeckS R Cummings
Mar 7, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D C NewittB MacDonald
Mar 9, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N J CrabtreeJ Reeve
Dec 5, 2002·Topics in Magnetic Resonance Imaging : TMRI·Felix W WehrliRichard Weening
Dec 20, 2002·Connective Tissue Research·G Boivin, P J Meunier
Jan 24, 2003·Seminars in Musculoskeletal Radiology·Thomas M Link, Jan S Bauer
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Maria BenitoPeter J Snyder
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yaotang WuMelvin J Glimcher
Sep 23, 2003·The New England Journal of Medicine·Dennis M BlackUNKNOWN PaTH Study Investigators
Sep 23, 2003·The New England Journal of Medicine·Joel S FinkelsteinRobert M Neer
Sep 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Thomas Beck
Sep 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Mary L Bouxsein

❮ Previous
Next ❯

Citations

May 22, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Ferrari
Sep 20, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S IshiiA Karlamangla
Sep 13, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R RizzoliD Felsenberg
Sep 1, 2012·Journal of Biological Physics·Nikolaos KourkoumelisMargaret Tzaphlidou
Sep 28, 2013·Current Rheumatology Reports·Elisa Torres-del-PliegoAdolfo Diez-Pérez
May 24, 2012·Endocrine·James F Griffith, Harry K Genant
Sep 21, 2013·Aging Clinical and Experimental Research·Monica CeliUmberto Tarantino
Nov 11, 2011·The Journal of Clinical Endocrinology and Metabolism·Shinya IshiiArun S Karlamangla
Jul 20, 2012·Annual Review of Nutrition·Sue A Shapses, Deeptha Sukumar
Mar 16, 2011·Journal of Osteoporosis·Athanassios KyrgidisKonstantinos Antoniades
Jun 2, 2012·TheScientificWorldJournal·Tomasz TopolińskiKrzysztof Nowicki
Aug 27, 2014·Calcified Tissue International·Samuel Gourion-ArsiquaudAdele L Boskey
Feb 24, 2012·Expert Opinion on Drug Metabolism & Toxicology·Luigi GennariRanuccio Nuti
Oct 28, 2014·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·C W BruceR J Runciman
Feb 7, 2013·British Journal of Clinical Pharmacology·Sandra Maria SaccoElizabeth Offord
Jul 23, 2011·Journal of Magnetic Resonance Imaging : JMRI·Dionyssios MintzopoulosYi-Qiao Song
Mar 2, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lin ShiJames F Griffith
Jun 23, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L Bouxsein
Apr 5, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eve DonnellyAdele L Boskey
Jul 29, 2015·IEEE Journal of Biomedical and Health Informatics·Marco VicecontiRod Hose
Mar 30, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·E Michael LewieckiUNKNOWN International Society for Clinical Densitometry
Jan 3, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sara M SprinkhuizenYi-Qiao Song
Jul 26, 2015·Wiener medizinische Wochenschrift·Nadja Fratzl-ZelmanPaul Roschger
May 2, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Konstantinos D Stathopoulos
Nov 12, 2013·Ultrasonics·Alexey TatarinovArmen Sarvazyan
Jun 25, 2016·Injury·Christian von Rüden, Peter Augat
Jul 1, 2016·Journal of Bone and Mineral Metabolism·Lingli ZhangJun Zou
Jun 30, 2016·The Journal of Endocrinology·Urszula T Iwaniec, Russell T Turner
May 24, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Monika Pawlowska, John P Bilezikian
Oct 5, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E Z MovassaghH Vatanparast
Oct 7, 2014·Applied Spectroscopy·Karen Esmonde-White
Nov 10, 2017·The Journal of Clinical Endocrinology and Metabolism·Deborah M MitchellSherri-Ann M Burnett-Bowie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Endocrinology, Diabetes, and Obesity
Sydney Lou Bonnick
Current Osteoporosis Reports
Mary L Bouxsein, David Karasik
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Adam D G Baxter-JonesDonald A Bailey
© 2022 Meta ULC. All rights reserved