Quantifying the ON and OFF Contributions to the Flash ERG with the Discrete Wavelet Transform

Translational Vision Science & Technology
Mathieu GauvinPierre Lachapelle

Abstract

Discrete wavelet transform (DWT) analyses suggest that the 20- and 40-Hz components of the short-flash photopic electroretinogram (ERG) are closely related to the ON and OFF pathways, respectively. With the DWT, we examined how the ERG ON and OFF components are modulated by the stimulus intensity and/or duration. Discrete wavelet transform descriptors (20, 40 Hz and 40:20-Hz ratio) were extracted from ERGs evoked to 25 combinations of flash durations (150-5 ms) and strengths (0.8-2.8 log cd.m(-2)). In ERGs evoked to the 150-ms stimulus (to separate the ON and OFF ERGs), the 40:20-Hz ratio of ON ERGs (mean ± SD: 0.49 ± 0.04) was significantly smaller (P < 0.05) than that of OFF ERGs (1.71 ± 0.18) owing to a significantly (P < 0.05) higher contribution of the 20 and 40 Hz components to the ON and OFF ERGs, respectively. With brighter stimuli, the ON and OFF components increased similarly (P < 0.05). While progressively shorter flashes had no impact (P > 0.05) on the ON component, it exponentially enhanced (P < 0.05) the OFF component. Discrete wavelet transform allows for an accurate determination of ON and OFF retinal pathways even in ERGs evoked to a short flash. To our knowledge, the significant OFF facilitatory effect evidenc...Continue Reading

Citations

Jun 27, 2020·Seminars in Ophthalmology·Soroor BehbahaniHamideh Sabbaghi
Jun 24, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Maja SustarAnthony G Robson
Feb 16, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Allison L DorfmanPierre Lachapelle
Jun 9, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Livia M BrandaoAnja M Palmowski-Wolfe
Nov 24, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Hamid AhmadiehSare Safi
Sep 10, 2021·Seminars in Ophthalmology·Samiyeh BakhshiNarsis Daftarian

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