Quantifying the relationship between gene expressions and trait values in general pedigrees

Genetics
Yan LuHong-Wen Deng

Abstract

Treating mRNA transcript abundances as quantitative traits and examining their relationships with clinical traits have been pursued by using an analytical approach of quantitative genetics. Recently, Kraft et al. presented a family expression association test (FEXAT) for correlation between gene expressions and trait values with a family-based (sibships) design. This statistic did not account for biological relationships of related subjects, which may inflate type I error rate and/or decrease power of statistical tests. In this article, we propose two new test statistics based on a variance-components approach for analyses of microarray data obtained from general pedigrees. Our methods accommodate covariance between relatives for unmeasured genetic effects and directly model covariates of clinical importance. The efficacy and validity of our methods are investigated by using simulated data under different sample sizes, family sizes, and family structures. The proposed LR method has correct type I error rate with moderate to large sample sizes regardless of family structure and family sizes. It has higher power with complex pedigrees and similar power to the FEXAT with sibships. The other proposed FEXAT(R) method is favorable wi...Continue Reading

References

Mar 1, 1983·American Journal of Medical Genetics·K Lange, M Boehnke
Oct 1, 1982·Annals of Human Genetics·J L Hopper, J D Mathews
Mar 1, 1996·Annals of Human Genetics·C I AmosE Boerwinkle
Jan 23, 1999·Nature Genetics·A Chakravarti
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
May 18, 2001·Genetical Research·M K Kerr, G A Churchill
Dec 19, 2001·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·R D WolfingerR S Paules
Mar 30, 2002·Science·Rachel B BremLeonid Kruglyak
Aug 3, 2002·Nature Reviews. Genetics·Yee Hwa Yang, Terry Speed
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Hong-Wen DengRobert R Recker
Nov 28, 2002·Nature Genetics·Vivian G Cheung, Richard S Spielman
Dec 24, 2002·Biometrics·Danh V NguyenRaymond J Carroll
Mar 21, 2003·Nature·Eric E SchadtStephen H Friend
Apr 11, 2003·American Journal of Human Genetics·Peter KraftSteve Horvath

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