Quantifying the return of headache in triptan-treated migraineurs: an observational study

Cephalalgia : an International Journal of Headache
F SheftellRichard B Lipton

Abstract

To improve understanding of secondary treatment failure in migraine patients, we evaluated 'headache return' as a novel endpoint to assess returning headaches according to their severity, expanding on current standard assessments of overall recurrence or relapse rates, in a six-month observational study of triptan-treated migraineurs. A total of 359 patients (91% female; mean age, 42.5 years) recorded data for 2168 headaches in electronic diaries. Two-thirds of headaches responded to triptan treatment (improved-to-mild or no pain two hours post-dose); 34% of headaches had a pain-free response. By 48 hours post-dose, 19% of all responding headaches returned; 24% of headaches achieving a pain-free response returned, predominantly to mild pain. More severe baseline headache, short duration since diagnosis of migraine, and female gender were associated with increased likelihood of headache return. Treatment satisfaction declined with increasing severity of headache return, demonstrating the value of assessing headache return by severity to fully evaluate its impact.

References

Feb 13, 2001·Cephalalgia : an International Journal of Headache·P Tfelt-HansenUNKNOWN International Headache Society Clinical Trials Subcommittee
Apr 23, 2002·Headache·Richard B LiptonJeffrey M Dayno
Apr 23, 2002·Headache·Julio Pascual
Jul 27, 2006·Headache·Jerome GoldsteinCarolyn R Sikes
Sep 6, 2008·Cephalalgia : an International Journal of Headache·D W Dodick

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Citations

Dec 10, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandro Della PuppaLuca Persano
Sep 30, 2010·The Journal of Headache and Pain·Anna FerrariEmilio Sternieri
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Flavia FranconiGennaro Bussone
Jun 3, 2011·Headache·E Anne MacgregorTobias Kurth
Mar 20, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nazia KarsanGregory Dussor
Nov 21, 2019·Cephalalgia : an International Journal of Headache·Kerry KnievelJoshua Tobin
Nov 20, 2020·Neurology·Daphne S van CasterenAntoinette MaassenVanDenBrink
May 3, 2011·Current Opinion in Neurology

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