Quantifying the rheological and hemodynamic characteristics of sickle cell anemia.

Biophysical Journal
Huan Lei, George Em Karniadakis

Abstract

Sickle erythrocytes exhibit abnormal morphology and membrane mechanics under deoxygenated conditions due to the polymerization of hemoglobin S. We employed dissipative particle dynamics to extend a validated multiscale model of red blood cells (RBCs) to represent different sickle cell morphologies based on a simulated annealing procedure and experimental observations. We quantified cell distortion using asphericity and elliptical shape factors, and the results were consistent with a medical image analysis. We then studied the rheology and dynamics of sickle RBC suspensions under constant shear and in a tube. In shear flow, the transition from shear-thinning to shear-independent flow revealed a profound effect of cell membrane stiffening during deoxygenation, with granular RBC shapes leading to the greatest viscosity. In tube flow, the increase of flow resistance by granular RBCs was also greater than the resistance of blood flow with sickle-shape RBCs. However, no occlusion was observed in a straight tube under any conditions unless an adhesive dynamics model was explicitly incorporated into simulations that partially trapped sickle RBCs, which led to full occlusion in some cases.

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Citations

Jan 15, 2014·Annals of Biomedical Engineering·Dmitry A FedosovSubra Suresh
Jun 13, 2013·Trends in Biotechnology·Zachary Grant MillsAlexander Alexeev
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Huan Lei, George E Karniadakis
May 15, 2013·Biomechanics and Modeling in Mechanobiology·Dmitry A FedosovGerhard Gompper
Mar 5, 2014·Hematology/oncology Clinics of North America·Abdullah Kutlar, Stephen H Embury
Jun 30, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhonglin Luo, Jianwen Jiang
Feb 9, 2016·Interface Focus·Xuejin LiGeorge Em Karniadakis
May 10, 2013·American Journal of Hematology·Justin WanekMahnaz Shahidi
Jan 3, 2016·The Journal of Chemical Physics·Ryan C Krafnick, Angel E García
Nov 29, 2014·Acta Ophthalmologica·Ali Kord ValeshabadMahnaz Shahidi
Aug 20, 2016·Rheologica Acta·Alireza YazdaniGeorge Em Karniadakis
Sep 22, 2012·Biophysical Journal·Xuejin LiGeorge Em Karniadakis
May 12, 2016·Biophysical Journal·Lu LuGeorge Em Karniadakis
Oct 8, 2015·Clinical Hemorheology and Microcirculation·Ali Kord ValeshabadMahnaz Shahidi
Mar 14, 2017·PLoS Computational Biology·Xuejin LiGeorge Em Karniadakis
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Jun 1, 2018·BioMed Research International·Tong Wang, Zhongwen Xing
Jun 19, 2018·Biomechanics and Modeling in Mechanobiology·Benjamin OwenAlistair Revell
Jul 16, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xin Yi, Huajian Gao
Jan 8, 2019·Biophysical Journal·Yixiang DengGeorge Em Karniadakis
Jun 5, 2021·Biophysical Journal·Elahe JavadiSafa Jamali
Oct 8, 2021·Biophysical Journal·Zixiang Leonardo LiuGeorge Em Karniadakis

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