Quantifying variability in the measurement of control in intermittent exotropia

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Sarah R HattJonathan M Holmes

Abstract

To evaluate the performance of a series of summary measures of control and to assess reliability in quantifying exodeviation control in intermittent exotropia. A large, simulated dataset of control scores for 10,000 hypothetical patients with intermittent exotropia was created using Monte Carlo simulations. These data were based on children with intermittent exotropia in whom control was assessed twice during one clinical examination, using the office control score (0-5). Each simulated patient had a baseline and 11 subsequent control scores. The repeatability of a series of summary measures of control (the mean of 2 vs the mean of 3 up to the mean of 6), was calculated using 95% limits of agreement (LOA). A total of 322 examinations in 152 patients were used to provide representative distributions of control scores. From the resultant Monte Carlo simulations, the 95% LOAs were 2.60 for 1 distance control score measure, 1.76 for the average of 3, and 1.28 for the average of 6. Therefore using the average of 3 scores, a change of <1.76 would be consistent with short-term variability, whereas a change of >1.76 would suggest a real change in control. The large dataset of simulated control scores allowed us to assess the variabilit...Continue Reading

References

Apr 1, 1993·Ophthalmology·R A StathacopoulosM Everett
Jan 23, 2004·The British Journal of Ophthalmology·H HaggertyM P Clarke
Jun 16, 2005·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Audrey ChiaQuah Boon Long
Sep 5, 2006·Strabismus·Brian G Mohney, Jonathan M Holmes
Jul 17, 2007·Ophthalmology·Sarah R HattJonathan M Holmes
Dec 19, 2008·Ophthalmology·Wendy E AdamsJonathan M Holmes
Jan 1, 2003·The American Orthoptic Journal·Judy L Petrunak, Rajesh Rao
Aug 17, 2011·American Journal of Ophthalmology·Sarah R HattJonathan M Holmes
Apr 25, 2012·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Sarah R HattJonathan M Holmes

❮ Previous
Next ❯

Citations

Aug 11, 2016·Ophthalmology·UNKNOWN Pediatric Eye Disease Investigator GroupAllison A Jensen
May 17, 2017·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Edward L Raab
Jul 5, 2017·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Cuiqing WangQi Wang
Jan 24, 2020·Journal of Pediatric Ophthalmology and Strabismus·Jungah HuhSeung-Hyun Kim
Dec 14, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Martin Ming-Leung MaXiang Chen
Mar 24, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Susan A CotterUNKNOWN Pediatric Eye Disease Investigator Group
Aug 7, 2018·Journal of Korean Medical Science·Jeong Min Kwon, Jae Ho Jung
Oct 11, 2017·Journal of Pediatric Ophthalmology and Strabismus·Seung Pil BangSe Youp Lee
May 27, 2020·Journal of Pediatric Ophthalmology and Strabismus·Wonyung Son, Won Jae Kim
Nov 20, 2020·Journal of Pediatric Ophthalmology and Strabismus·Sharlene Marie PrileHyun Taek Lim
Mar 5, 2021·JAMA Ophthalmology·Angela M ChenUNKNOWN Pediatric Eye Disease Investigator Group
Aug 18, 2020·Journal of Optometry·Martin Ming-Leung MaMeihua Le
Aug 27, 2021·Journal of Pediatric Ophthalmology and Strabismus·Wenquan TangXuanchu Duan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pediatric Ophthalmology and Strabismus
Michael P Clarke
Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
L A WalshF Tremblay
Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Sarah R HattJonathan M Holmes
American Journal of Ophthalmology
Sarah R HattJonathan M Holmes
© 2022 Meta ULC. All rights reserved