Quantitation and karyometry of cerebral neuroglia and endothelial cells in liver cirrhosis and in the hepatosplenic schistosomiasis mansoni

Acta Neuropathologica
G Brasileiro-FilhoJ E Pittella

Abstract

A morphological, karyometric, and quantitative study of cerebral neuroglia and endothelial cells of blood capillaries was done in cirrhotic and in hepatosplenic schistosomotic human autopsied cases. Cluster analysis applied to them revealed three subgroups (cirrhosis and schistosomiasis polar groups and one intermediate). The comparison of these three groups with a control revealed increased numbers of astrocytes, oligodendrocytes and endothelial cells, but no nuclear enlargement in the schistosomiasis group; the cirrhosis group exhibited a pronounced nuclear enlargement of both astrocyte and oligodendrocytes but no increase in cell numbers. The intermediate group, which encompasses the majority of pathological cases, is heterogeneous but on average behave as the cirrhosis group in that nuclear enlargement, but no increase in cell numbers, was noted. Such changes could represent a response of the nervous system to the metabolic disturbances present in hepatic and/or portal-systemic encephalopathy. There was a positive correlation between glial and endothelial cell numbers in cerebral cortex, suggesting a functional relationship between the glial cells and the capillary bed. This study points out the importance of clustering the...Continue Reading

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Jun 1, 1977·Acta Neurologica Scandinavica·N H Diemer, H Laursen
Jul 15, 1977·Acta Neuropathologica·N H DiemerL Klinken
Jan 1, 1973·Journal of the Neurological Sciences·A J ZamoraM H Kyu
Jan 1, 1971·Journal of the Neurological Sciences·J B Cavanagh, M H Kyu
Jan 1, 1971·Annals of Surgery·D G KlineF C Nance
Jan 1, 1959·Archiv für Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie·W SCHLOTE

❮ Previous
Next ❯

Citations

Mar 12, 2005·Emerging Infectious Diseases·Valerianna AmorosaEmily Blumberg
May 18, 2016·The Journal of Comparative Neurology·Christopher S von BartheldSuzana Herculano-Houzel
Nov 19, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jami Bahney, Christopher S von Bartheld
Nov 15, 2018·Frontiers in Neuroanatomy·Bruna Valério-GomesRoberto Lent

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.