PMID: 8602674Feb 1, 1996Paper

Quantitation of depth of thiopental anesthesia in the rat

Anesthesiology
L L GustafssonD R Stanski

Abstract

In contrast to that of inhalational anesthetics, quantitation of anesthetic depth for intravenous agents has not been well defined. In this study, using rodents, the relationship between the constant plasma thiopental concentrations and the clinical response to multiple nociceptive stimuli were investigated characterizing the anesthetic state from light sedation to deep anesthesia and correlated to the degree of electroencephalogram (EEG) drug effect. Thirty rats were instrumented with chronically implanted EEG electrodes, arterial and venous catheters. A computer-driven infusion pump was used to rapidly attain and then maintain constant, target plasma thiopental concentrations ranging from 7 to 100 micrograms/ml. Three different target plasma thiopental concentrations were achieved in each rat. Electroencephalographic effects were monitored with aperiodic waveform analysis. The following nociceptive stimuli were applied: (1) unprovoked righting reflex, (2) provoked righting reflex, (3) noise stimulus, (4) tail clamping with an alligator clip, (5) constant tail pressure with an analgesiameter, (6) corneal reflex, and (7) tracheal intubation. For tail clamping, tail pressure, and intubation, either purposeful extremity movement ...Continue Reading

References

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Citations

Jul 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D P ArcherS H Roth
Dec 24, 1997·Electroencephalography and Clinical Neurophysiology·H S LukatchP M Werchan
Feb 27, 1999·Toxicology Letters·N P Franks, W R Lieb
May 1, 1997·Experimental Gerontology·H HarashimaD R Stanski
Jan 6, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·H DownesN Lessov
Oct 6, 1997·Acta Anaesthesiologica Scandinavica·O NordströmR Sandin
Apr 2, 2010·Anesthesia and Analgesia·Wen-Jun LuoJing Gan
Apr 20, 2002·Anesthesiology·Robert DickinsonNicholas P Franks
Apr 27, 2005·Anesthesiology·Olga A ImasAnthony G Hudetz
Sep 1, 2012·European Journal of Anaesthesiology·Chieh-Shou SuTsun-Jui Liu
Sep 29, 2001·British Journal of Anaesthesia·A Descorps-DeclèreY Lecarpentier
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·N LealE Suarez
Nov 25, 2003·Journal of Veterinary Pharmacology and Therapeutics·L M AntunesP A Flecknell
Aug 7, 2020·Fundamental & Clinical Pharmacology·Doaa AbdelmoneimEl Said El-Sherbini
Mar 21, 2017·Journal of Neuroscience Research·Sarah SonnayRolf Gruetter

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