PMID: 1098450Aug 1, 1975Paper

Quantitation of intestinal-tissue layers from their histology

The American Journal of Digestive Diseases
M K Younoszai, J C Ranshaw

Abstract

A line-sampling technique was applied to microscopic histology of human peroral small-intestinal biopsies to quantitate the relative proportions of the tissue layers. In healthy individuals the villus epithelium formed 41--46%, the crypt epithelium 20--26%, and the lamina propria 34% of the mucosa. In gluten enteropathy the villus epithelium formed 7%, crypt epithelium 43%, and lamina propria 50% of the mucosa. In individuals suffering from chronic diarrhea with malabsorption, the percentages of the tissue components were intermediate between those of healthy individuals and those with gluten enteropathy. The validity of the technique was tested in male and female rats with different intestinal size. In adjacent segments, the actual weight of the scraped mucosa and that of the underlying tissues correlated very well with their corresponding weights estimated from the microscopic histology, using the line-sampling technique. The intestinal-tissue layers quantitated were the villus epithelium, crypt epithelium, the lamina propria + muscularis mucosae+submucosa, and the muscle+serosal coats.

References

Sep 11, 1965·Lancet·J P StanfieldR Tunnicliffe
Oct 1, 1972·The American Journal of Physiology·M K Younoszai, H P Schedl
Mar 1, 1972·Journal of Clinical Pathology·M S Dunnill, R Whitehead
Mar 1, 1970·The American Journal of Physiology·R F HagemannS Lesher
Sep 1, 1970·The American Journal of Anatomy·R F HagemannS Lesher
Apr 1, 1971·The Journal of Experimental Zoology·H P Schedl, H D Wilson
Apr 1, 1969·The Anatomical Record·D R McCabeC A Hogben
Aug 1, 1960·American Journal of Clinical Pathology·W M THURLBECKH R DUDLEY
Jan 1, 1965·The American Journal of Medicine·N MADANAGOPALANB ROWE

Citations

Apr 1, 1986·Digestive Diseases and Sciences·C B RodningS L Erlandsen

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.