PMID: 7082775Jan 1, 1982Paper

Quantitation of iprindole in plasma by GLC

Biopharmaceutics & Drug Disposition
G CailleJ G Besner


A specific, sensitive, rapid, and reproducible method for iprindole in human plasma was developed using gas chromatography with trimipramine as internal standard. The sensitivity of the method is of 5 ng ml-1 and a linearity was obtained for concentrations ranging from 12.5 ng ml-1 to 100 ng ml-1 with a regression coefficient of 0.9872. The plasma levels of iprindole were determined in five healthy volunteers following the administration of a single oral dose of 60 mg and in four patients admitted for endogenous depression after a 3-week administration of 90 mg d-1. Following a single oral dose to healthy volunteers, the maximum concentrations occurred between 2 and 4 h after administration of the drug and the mean half-life value was 52.5 h. In patients the steady-state concentrations of iprindole ranged between 18 and 77 ng ml-1.


Nov 15, 1977·Psychopharmacology·L F GramO Krautwald
Dec 1, 1977·Clinical Pharmacology and Therapeutics·D J KupferP Coble
Sep 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·K RickelsJ H Simon
Jan 1, 1972·Current Medical Research and Opinion·R S Master, J B Bastani
Sep 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·N K el-DeiryS K Littmann
Feb 1, 1972·Archives of General Psychiatry·W E FannJ A Oates

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