Quantitation of localized (31)P magnetic resonance spectra based on the reciprocity principle

Journal of Magnetic Resonance
Roland KreisChris Boesch

Abstract

There is a need for absolute quantitation methods in (31)P magnetic resonance spectroscopy, because none of the phosphorous-containing metabolites is necessarily constant in pathology. Here, a method for absolute quantitation of in vivo (31)P MR spectra that provides reproducible metabolite contents in institutional or standard units is described. It relies on the reciprocity principle, i.e., the proportionality between the B(1) field map and the map of reception strength for a coil with identical relative current distributions in receive and transmit mode. Cerebral tissue contents of (31)P metabolites were determined in a predominantly white matter-containing location in healthy subjects. The results are in good agreement with the literature and the interexamination coefficient of variance is better than that in most previous studies. A gender difference found for some of the (31)P metabolites may be explained by different voxel composition.

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Citations

Jan 5, 2011·PloS One·Kenneth I MarroMartin J Kushmerick
Jul 26, 2006·Radiology·Jacobus F A JansenM Eline Kooi
Apr 15, 2015·NMR in Biomedicine·Dinesh Kumar DeelchandPierre-Gilles Henry
Feb 22, 2018·NMR in Biomedicine·Niklaus ZoelchAnke Henning
Aug 31, 2002·NMR in Biomedicine·J Eric JensenPeter C Williamson
Apr 11, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Xiao-Hong ZhuWei Chen
May 30, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·U SeegerU Klose
Apr 23, 2002·NMR in Biomedicine
Dec 22, 2004·Journal of Magnetic Resonance Imaging : JMRI·Gregor JostSabine Heiland
Nov 15, 2016·Analytical Biochemistry·Veronika RackayovaOlivier Braissant

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