Quantitation of mast cells and collagen fibers in skin tags.

Indian Journal of Dermatology
Omar Soliman El SafouryDalia H Mohamed

Abstract

Skin tags are common benign skin tumors usually occurring on the neck and major flexors of elder people. The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and nondiabetics, to find a possible correlation between mast cells and collagen fibers in the pathogenesis of skin tags. Thirty participants with skin tags were divided into two groups (15 diabetic and 15 nondiabetic). Three biopsies were obtained from one anatomical site: A large skin tag, a small skin tag, and adjacent normal skin. Mast cells stained with Bismarck brown were counted manually in ten different fields of each section with magnification x1000 and the average count was correlated with the percentage of mean collagen area in five fields done by the image analyzer. A statistically significant correlation between mast cell count and percentage of collagen mean area was detected in both studied groups (except in large skin tags of the nondiabetic group). The positive correlation between mast cell count and percentage of collagen mean area suggests the critical role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts.

References

Jul 1, 1987·The British Journal of Dermatology·J S MarshallE B Bell
Jan 1, 1989·Annals of the New York Academy of Sciences·M E Rothenberg, K F Austen
Aug 1, 1989·American Journal of Obstetrics and Gynecology·D Muram
Jun 1, 1983·Annals of Internal Medicine·J LeavittD H VanThiel
Jun 26, 1998·The British Journal of Dermatology·C DianzaniA M Degener
May 29, 1999·Obesity Research·L García-HidalgoG Ortiz-Pedroza
Apr 20, 2001·Journal of the American Academy of Dermatology·E Chiritescu, M E Maloney
May 23, 2001·Journal of the American Academy of Dermatology·S EuvrardA Claudy
Sep 23, 2003·Current Opinion in Allergy and Clinical Immunology·Abraham SolomonFrancesca Levi-Schaffer
Jul 1, 2004·The British Journal of Surgery·B SinghB George
Jul 11, 2006·Clinics in Dermatology·Anat Ben-Shlomo, Shlomo Melmed

❮ Previous
Next ❯

Citations

Oct 4, 2011·Indian Journal of Dermatology·Omar Soliman El Safoury, Magdy Ibrahim
Jun 1, 2013·Indian Journal of Dermatology·Samar Abdallah M SalemMarwa A El Gendy
Dec 23, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·M A ShaheenA A Saad
Aug 25, 2020·Human Antibodies·Burcu BeksacMehmet Sinan Beksac

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Arcus
Excel
Arcus QuickStat
Image analyzer
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Emilio SudyTeresa Sir
The Journal of Spinal Cord Medicine
Joshua M PahysRandal R Betz
© 2021 Meta ULC. All rights reserved