Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos

Journal of Agricultural and Food Chemistry
Betina B StrassmannMarcelo Maraschin

Abstract

Methylxanthinic alkaloids and phenolic compounds are related to the therapeutic properties of Ilex paraguariensis infusions. Considering the known vascular tropism of xanthines, an aqueous extract (mate) and caffeine were evaluated on blood vessel formation, in connection with the analysis of those secondary metabolites, which was performed in young and mature leaf samples collected in three cultivation systems located in the southern region in Brazil (Santa Catarina State). Samples of young and mature leaves from a monoculture cultivation system (MC) showed the highest content of phenolic compounds (149.68 microg/mL, young leaves; 135.50 microg/mL, mature leaves) and caffeine (young leaves, 148.07 microg/mL; mature leaves, 244.63 microg/mL) as compared to samples from agroforesty (AF) and shaded-native (NT) cultures. Theophylline was not detected in samples by reverse phase-high performance liquid chromatography, and mature leaves showed lower theobromine amounts (11.46 microg/mL). Treatments performed with mate aqueous extract and caffeine (1.03-4.12 microM/disk) in the yolk sac vascular membranes of 2-day-old chick embryos revealed pro-vasculo- and angiogenic properties as well as embryonic growth enhancement. These findings...Continue Reading

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Citations

Apr 12, 2014·TheScientificWorldJournal·Wen-Ying HuangYung-Sheng Lin
Jan 8, 2011·Experimental Lung Research·Manuella LanzettiSamuel Santos Valenca
Jul 6, 2010·Journal of Ethnopharmacology·N BracescoA Gugliucci
Feb 27, 2016·The British Journal of Nutrition·Vilma Pereira PanzaEdson Luiz da Silva
Jun 19, 2013·Food Chemistry·Aureanna Nairne Negrão MurakamiMarcelo Maraschin
Oct 25, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fernanda de AndradeEdson Luiz da Silva
Sep 5, 2019·Plant Foods for Human Nutrition·Aline Minuzzi BeckerEdson Luiz da Silva
Jun 5, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Débora Santos RochaLuiz Carlos Kucharski

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