Quantitation of serum antibodies to surface antigens of group B streptococci types Ia, Ib, and III: low antibody levels in mothers of neonatally infected infants

Scandinavian Journal of Infectious Diseases
K K ChristensenN Svenningsen

Abstract

A method has been developed for the detection in human sera of antibodies to surface antigens of group B streptococci (GBS), types Ia, Ib, or III. The sera were absorbed with GBS type II and then added to a suspension of GBS of the type against which antibodies were to be measured. After incubation and washing of the bacteria, the antibodies present on the surface of the cells were quantitated with radiolabelled protein A. Antibodies of IgG class were detected, probably specific for types Ia, Ib, or III, with the exception that the Ib GBS suspension used could detect some antibodies to type Ia. With this method it was found that 6/7 mothers to infants with GBS septicemia had low levels of serum antibodies to the infant's type of GBS. Urogenital carriers of GBS, giving birth to neonatally healthy infants, had higher serum antibody levels against the colonizing type.

References

Jan 1, 1979·The Journal of Experimental Medicine·J Y TaiR C Lancefield
Dec 1, 1976·The Journal of Clinical Investigation·V G HemmingH R Hill
Nov 1, 1977·The Journal of Infectious Diseases·P B Stewardson-KriegerS P Gotoff
Jan 1, 1978·Scandinavian Journal of Infectious Diseases·G BjörkhemC Schalén
Jan 1, 1978·Scandinavian Journal of Infectious Diseases·K K Christensen, P Christensen
Jan 1, 1976·Scandinavian Journal of Infectious Diseases·K V ChristensenP Christensen
Jan 1, 1966·International Archives of Allergy and Applied Immunology·P J McConahey, F J Dixon
Jan 1, 1974·Scandinavian Journal of Immunology·M Harboe, I Fölling
Sep 1, 1973·Gut·C A LoehryJ Baker

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Citations

Nov 1, 1983·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K K ChristensenV Lindén
Apr 1, 1983·European Journal of Pediatrics·K K ChristensenN Svenningsen
Jun 1, 1984·European Journal of Pediatrics·K K ChristensenR A Seger
Aug 1, 1985·American Journal of Obstetrics and Gynecology·A G SkidmoreA Smith
Jun 24, 2010·Clinics in Perinatology·Jennifer R Verani, Stephanie J Schrag
Nov 1, 1988·The Journal of Infection·H CarstensenS Polberger
Aug 1, 1984·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P BelfrageB Wretlind
Jan 1, 1980·Scandinavian Journal of Infectious Diseases·K K ChristensenP Christensen
Dec 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·C SchalénP Christensen
May 10, 2017·Open Forum Infectious Diseases·Anne-Marie RickEdwin J Asturias
Jan 1, 1981·Scandinavian Journal of Infectious Diseases·K K ChristensenP Christensen
Sep 1, 1987·Acta Oto-laryngologica·A Stjernquist-DesatnikP Christensen
Apr 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·V Lindén
Dec 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·C SöderströmA G Sjöholm
Jun 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·S Håkansson, S Holm
Jun 1, 1983·Current Problems in Pediatrics·K L CatesM Ballow

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