PMID: 9160914Jan 1, 1997Paper

Quantitation of shock wave cavitation damage in vitro

Ultrasound in Medicine & Biology
D A LifshitzJames A McAteer

Abstract

Acoustic cavitation damage was quantitated using aluminum foil targets placed within 2-mL polypropylene cryovials. The vials contained various media tested for their potential to support cavitation and were exposed to shock waves using an unmodified Dornier HM3 lithotripter. Foil damage, expressed in terms of a "damage index," was measured from digitized light microscopy images by quantitating the spread of gray-scale histograms. Target sensitivity was demonstrated by reproducible dose-response curves over the range (1-200 shock waves) commonly used for in vitro cell injury studies. Increased shock wave repetition rate reduced the damage index. Untreated foils showed a very low damage index (0.001% +/- 0.001%), while treated foils submerged in Ringer buffer yielded significant damage (2.2% +/- 0.3%, p < 0.001). Degassing the buffer reduced damage to 0.3% +/- 0.1% (p < 0.001). Foils submerged in castor oil showed virtually no damage. These results implicate acoustic cavitation in target damage. Targets immersed in biological fluids (blood and urine) had significantly less damage than in Ringer. The effect of degassing was also evaluated in a red blood cell lysis assay. Hemoglobin release in degassed preparations was significantl...Continue Reading

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Citations

Oct 29, 2002·Ultrasound in Medicine & Biology·Thomas J MatulaLawrence A Crum
Jul 25, 2003·Ultrasound in Medicine & Biology·Dahlia L SokolovLawrence A Crum
Jun 22, 1999·Ultrasound in Medicine & Biology·J C WilliamsJ A McAteer
Jun 22, 1999·Ultrasound in Medicine & Biology·S D Pye, J A Dineley
Jan 8, 2000·Ultrasound in Medicine & Biology·J C WilliamsJ A McAteer
Dec 10, 2002·Journal of Endourology·Ryan F PatersonJames A McAteer
Jan 25, 2003·Journal of Endourology·Dahlia L SokolovAndrew P Evan
Oct 21, 2003·Journal of Endourology·Yuriy A PishchalnikovJames A McAteer
Dec 4, 2003·Journal of Endourology·James E LingemanAndrew P Evan
Mar 1, 2005·Journal of Endourology·Lynn R WillisJames E Lingeman
Oct 9, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Youzhi ShaoJames E Lingeman
Sep 21, 2006·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Anders SondénB Thomas Kjellström
Sep 24, 2005·Ultrasound in Medicine & Biology·Michael R BaileyAndrew P Evan
Jun 2, 2016·IEEE Reviews in Biomedical Engineering·Morteza GhorbaniAli Kosar
Oct 2, 2002·Lasers in Surgery and Medicine·Anders SondénB Thomas Kjellström
Aug 27, 1999·The Journal of the Acoustical Society of America·M R BaileyL A Crum
Sep 27, 2001·The Journal of the Acoustical Society of America·D L SokolovL A Crum
Mar 30, 2000·The Journal of the Acoustical Society of America·R O ClevelandL A Crum
Apr 28, 2001·Physics in Medicine and Biology·M LokhandwallaB Sturtevant
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Jun 20, 2002·Current Opinion in Urology·Ryan F PatersonJames E Lingeman
Dec 16, 2003·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Lucia MartiniRoberto Giardino

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