Quantitation of structural features characterizing weight- and less-weight-bearing regions in articular cartilage: a stereological analysis of medial femoral condyles in young adult rabbits

The Anatomical Record
P EggliR K Schenk

Abstract

The structural organization of articular cartilage from the medial femoral condyle of young adult rabbits has been examined after processing according to an improved fixation procedure. By using recently developed stereological methods, a quantitative analysis of chondrocyte number, surface area, volume, and matrix volume per cell was carried out in the light microscope; at the electron microscopic level, quantities of cytoplasmic components within chondrocytes (including organelles) were estimated. These measurements were made for each of the four zones from the (articular cartilage) surface down to the tidemark, and the results (for each zone) were compared between weight- and less-weight-bearing regions. In general, articular cartilage revealed considerable heterogeneity in structure throughout its depth. The number of cells per unit volume is maximal beneath the surface and decreases toward the tidemark. The size of chondrocytes, and the mean matrix volume surrounding each, increases from the surface toward the deeper zones. Comparison between weight- and less-weight-bearing regions reveals striking differences. The numerical volume density of cells in the superficial zone of regions bearing high physiological load is less ...Continue Reading

References

Jul 17, 1975·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Maroudas
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J DunhamI H Muir
Jan 1, 1986·Cell Biochemistry and Function·J DunhamI H Muir
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·I MasoudA Moses
Jun 1, 1986·Journal of Microscopy·A J BaddeleyL M Cruz-Orive
Apr 1, 1986·International Journal of Sports Medicine·J JurvelinH J Helminen
Jul 1, 1986·Journal of Microscopy·L M Cruz-Orive, E B Hunziker
Sep 1, 1985·Cell Biology International Reports·C J HandleyD J McQuillan
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P G BulloughA L Boskey
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J M Clark
Mar 1, 1985·The Anatomical Record·P S EggliR K Schenk
Jul 21, 1970·Biochimica Et Biophysica Acta·G E KempsonM A Freeman
Jan 1, 1967·Annals of the Rheumatic Diseases·G Meachim, S Roy
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J R ZirnR L Smith
Nov 1, 1984·Arthritis and Rheumatism·C T BrightonR M Hunt
Dec 1, 1984·The Anatomical Record·K PaukkonenH J Helminen
Feb 1, 1983·The Biochemical Journal·M T BaylissS Y Ali
Jun 1, 1984·Arthritis and Rheumatism·M J Palmoski, K D Brandt
Jun 1, 1981·Journal of Microscopy·L M Cruz-Orive, E R Weibel
Mar 1, 1980·Arthritis and Rheumatism·M J PalmoskiK D Brandt

❮ Previous
Next ❯

Citations

Jun 1, 1996·Journal of Biomedical Materials Research·B C ToolanH Alexander
Apr 1, 1996·Arthritis and Rheumatism·T HayashiH E Jasin
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H J DonahueP R Brink
Oct 6, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·M B Quintana-VillamandosE Delgado-Baeza
Mar 1, 2006·Biomechanics and Modeling in Mechanobiology·Rami K KorhonenJukka S Jurvelin
Jun 18, 2010·Annals of Biomedical Engineering·Emily E Coates, John P Fisher
Mar 5, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Jun ChenLori A Setton
Feb 24, 1999·Journal of Anatomy·M Benjamin, J R Ralphs
Apr 11, 2008·Tissue Engineering. Part a·Lindsay C DaviesVictor C Duance
Apr 23, 2011·Tissue Engineering. Part B, Reviews·Kara L SpillerAnthony M Lowman
Nov 27, 2004·Spine·Lori A Setton, Jun Chen
Feb 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H HedlundO Svensson
Jun 8, 2004·Journal of Biomechanical Engineering·Mathieu CharleboisMichael D Buschmann
Apr 13, 2012·The Journal of Experimental Biology·Kimberly A CongdonMatthew J Ravosa
Feb 21, 2009·The Journal of Bone and Joint Surgery. American Volume·Thomas P AndriacchiSean F Scanlan
Jan 6, 2009·American Journal of Veterinary Research·Rachel C MurrayAllen E Goodship
Mar 26, 2014·Nature Reviews. Rheumatology·Hang Fang, Frank Beier
Nov 24, 2012·Biotechnology Advances·Syam P Nukavarapu, Deborah L Dorcemus
May 31, 2013·Journal of Biomechanical Engineering·Victor K LaiVictor H Barocas
Aug 15, 2006·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Andreas H GomollBrian J Cole
Jan 28, 2016·Regenerative Biomaterials·Xuezhou LiXuesi Chen
Oct 24, 2012·Journal of Biomechanics·Ryan MaddenWalter Herzog
May 24, 2014·Biomechanics and Modeling in Mechanobiology·Ryan M J MaddenWalter Herzog
Sep 1, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Ernst B HunzikerNahoko Shintani
Feb 16, 2006·Osteoarthritis and Cartilage·E M DarlingF Guilak
Feb 10, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·S R McGlashanC A Poole
Aug 12, 2008·Biophysical Journal·Holly A Leddy, Farshid Guilak
Sep 16, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E LangelierM D Buschmann
May 10, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kyle D JadinRobert L Sah
Oct 4, 2008·The American Journal of Sports Medicine·Andreas H GomollBrian J Cole
Dec 1, 2015·Biochemical and Biophysical Research Communications·Cheng ChenLiu Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.