PMID: 9179459Apr 1, 1997Paper

Quantitation of vaginally administered nonoxynol-9 in premenopausal women

Contraception
P Barditch-CrovoC B Trapnell

Abstract

A feasibility study was performed in 11 healthy nonpregnant premenopausal women to determine a method for collection and recovery of vaginally administered nonoxynol-9. We also determined if nonoxynol-9 could be quantitated in vaginal lavage fluid obtained 2 h after instillation of a standard precoitol dose of a foam formulation of nonoxynol-9. Samples were analyzed in batch using a validated normal phase high-performance liquid chromatography (HPLC) method. Two hours after instillation of one dose of Delfen Contraceptive Foam (100 mg), the quantity of nonoxynol-9 collected ranged from 10.8 to 67.8 mg (mean: 35.4 mg). This corresponds to a recovery of 11.70%, of the administered dose. Quantitation of vaginally administered nonoxynol-9 is both practical and feasible. These data represent a critical first step in the evaluation of the safety and effectiveness of nonoxynol-9-containing products in the prevention of sexually transmitted diseases.

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Citations

Jul 15, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F R WitterC B Trapnell
Nov 10, 2004·Fertility and Sterility·Paul G McDonough
Jan 2, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Vidya Iyer, S S Poddar

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