Quantitative accuracy of (177)Lu SPECT reconstruction using different compensation methods: phantom and patient studies

EJNMMI Research
Eero HippeläinenA Sohlberg

Abstract

In targeted radionuclide therapy (TRT), accurate quantification using SPECT/CT images is important for optimizing radiation dose delivered to both the tumour and healthy tissue. Quantitative SPECT images are regularly reconstructed using the ordered subset expectation maximization (OSEM) algorithm with various compensation methods such as attenuation (A), scatter (S) and detector and collimator response (R). In this study, different combinations of the compensation methods are applied during OSEM reconstruction and the effect on the (177)Lu quantification accuracy is studied in an anthropomorphic torso phantom. In addition, the phantom results are reflected to (177)Lu-DOTA-Tyr3-octreotate ((177)Lu-DOTATATE)-treated patient data and kidney absorbed dose estimates. The torso phantom was imaged with nine various sized (0.4-104.4 cm(3)) spherical inserts, filled with known (177)Lu activity ranging from 0.5 to 105.5 MBq. Images were reconstructed using OSEM algorithm using A, AR and ARS compensation method combinations. The compensation method combinations were compared by calculating the concentration recovery coefficient (cRC) for each insert. In addition, ten (177)Lu-DOTATATE-treated patient's post-therapy dosimetry acquisitions ...Continue Reading

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Citations

May 25, 2016·Acta Oncologica·Jorma HeikkonenMikko Tenhunen
Oct 4, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·M D'ArienzoL Strigari
Aug 15, 2017·PloS One·Emilio MezzengaAnna Sarnelli
Mar 5, 2019·EJNMMI Physics·John DicksonStefan Vöö
Jan 8, 2017·EJNMMI Physics·Carlos F UribeAnna Celler
Mar 23, 2018·Annals of Nuclear Medicine·Tobias Bexelius, Antti Sohlberg
Jul 3, 2020·EJNMMI Physics·I MarinP Bernhardt
Aug 30, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tobias RydénPeter Bernhardt
Apr 4, 2021·Revista española de medicina nuclear e imagen molecular·T Monserrat FuertesP Mínguez Gabiña
Jun 1, 2021·Annals of Nuclear Medicine·Yuya SekikawaMasayuki Sasaki

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Software Mentioned

MIRD Pamphlet
HERMES HybridRecon
OSEM

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