Quantitative airway assessment on computed tomography in patients with alpha1-antitrypsin deficiency.

COPD
Tsuneo YamashiroGeorge R Washko

Abstract

The relationship between quantitative airway measurements on computed tomography (CT) and airflow limitation in individuals with severe alpha (1)-antitrypsin deficiency (AATD) is undefined. Thus, we planned to clarify the relationship between CT-based airway indices and airflow limitation in AATD. 52 patients with AATD underwent chest CT and pre-bronchodilator spirometry at three institutions. In the right upper (RUL) and lower (RLL) lobes, wall area percent (WA%) and luminal area (Ai) were measured in the third, fourth, and fifth generations of the bronchi. The severity of emphysema was also calculated in each lobe and expressed as low attenuation area percent (LAA%). Correlations between obtained measurements and FEV(1)% predicted (FEV(1)%P) were evaluated by the Spearman rank correlation test. In RUL, WA% of all generations was significantly correlated with FEV(1)%P (3rd, R = -0.33, p = 0.02; 4th, R = -0.39, p = 0.004; 5th, R = -0.57, p < 0.001; respectively). Ai also showed significant correlations (3rd, R = 0.32, p = 0.02; 4th, R = 0.34, p = 0.01; 5th, R = 0.56, p < 0.001; respectively). Measured correlation coefficients improved when the airway progressed distally from the third to fifth generations. LAA% also correlated ...Continue Reading

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Citations

Jul 2, 2014·Annals of the American Thoracic Society·Eric A HoffmanR Graham Barr
May 7, 2013·Journal of Behavioral Medicine·Kristen E HolmFrederick S Wamboldt
Apr 3, 2013·COPD·Charlie Strange
Mar 6, 2013·Chest·Alejandro A DiazGeorge R Washko
May 19, 2010·Respiratory Physiology & Neurobiology·Plamen BokovChristophe Delclaux
Dec 14, 2011·Respiratory Medicine·M Els BakkerBerend C Stoel
Dec 6, 2018·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Manuela Brisot FelisbinoAlberto Cukier

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