Quantitative analyses of synaptic contacts of interneurons in the dorsal lateral geniculate nucleus of the squirrel monkey

Visual Neuroscience
J R WilsonR P Cramer

Abstract

Three interneurons were recorded from and then injected with horseradish peroxidase in the parvocellular laminae of the squirrel monkey's (Saimiri sciureus) dorsal lateral geniculate nucleus. They were then examined using the electron microscope for their synaptic contacts, both the afferent contacts onto their dendrites and their presynaptic dendritic contacts onto presumptive projection (relay) neuron dendrites. The somata of these interneurons were small (mean = 178 microns 2), but the dendritic trees were large compared with those of projection neurons. All three interneurons had similar synaptic patterns onto their dendrites with about equal numbers of retinal, cortical, and GABAergic contacts. The distribution of these contacts was more uniform compared with the same types of contacts made onto projection neurons. The presynaptic dendrites were observed to contact only the dendrites of presumptive projection neurons, and these contacts were nearly all in the form of geniculate triads. None of the three interneurons displayed an axon. The receptive fields of these interneurons were similar to those of projection cells, but were larger and had center-response signs that were the opposite of the projection neurons around the...Continue Reading

References

May 1, 1978·Journal of Neurophysiology·P H Schiller, J G Malpeli
Dec 1, 1978·The Journal of Comparative Neurology·J H KaasJ K Harting
Jan 1, 1992·Progress in Brain Research·D J Uhlrich, J B Cucchiaro
Jan 1, 1992·Progress in Brain Research·T T Norton, D W Godwin
Jan 1, 1988·Visual Neuroscience·J R Wilson, A E Hendrickson
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C R Michael
Mar 29, 1973·Experimental Brain Research·P PasikJ Szentágothai
Nov 1, 1966·Journal of Neurophysiology·T N Wiesel, D H Hubel
Nov 1, 1967·The Journal of Physiology·H B BarlowJ D Pettigrew
Jun 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J R WilsonS M Sherman
Dec 1, 1984·The Journal of Physiology·A M Derrington, P Lennie
Nov 25, 1982·Nature·S LeVay, S K McConnell
Jan 1, 1980·Vision Research·P Lennie

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Citations

Oct 3, 2002·The Journal of Comparative Neurology·Diana L CoomesBrett R Schofield
Sep 15, 2018·International Journal of Neural Systems·Pablo Martínez-CañadaFrancisco Pelayo

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