Quantitative analysis and effect of attenuation correction on lymph node staging of non-small cell lung cancer on SPECT and CT

AJR. American Journal of Roentgenology
Shinya ShiraishiYasuyuki Yamashita

Abstract

The purpose of our study was to assess quantitative indexes and the effect of attenuation correction on the evaluation of lymph node metastasis in the staging of non-small cell lung cancer (NSCLC) using fused thallium-201 SPECT/CT images. We evaluated 156 lymph nodes (66 metastatic, 90 nonmetastatic) from 29 patients with NSCLC. Using our combined SPECT/CT system, all patients underwent 201Tl SPECT and CT examinations immediately (early images) and 3 hr after (delayed images) the injection of 201Tl. SPECT images were reconstructed with and without attenuation correction. For the quantitative evaluation of lymph node metastasis, we calculated the early ratio, the delayed ratio, and the washout ratio for SPECT images and the short-axis diameter for CT images. Receiver operating characteristic (ROC) analysis was performed in each index for the differentiation between metastatic and nonmetastatic lymph nodes. Visual analysis was also performed by two experienced radiologists. The area under the ROC curve (A(z)) showed that early ratio and delayed ratio were superior to short-axis diameter for the assessment of lymph node metastasis. In addition, early and delayed ratios on attenuation-corrected images were superior to those ratios ...Continue Reading

References

Nov 4, 1998·Medical Physics·P E KinahanD Sashin
Dec 16, 1998·Nuclear Medicine Communications·A S ArbabT Araki
Sep 9, 1999·Radiology·E M MaromE F Patz
Feb 5, 2000·Seminars in Surgical Oncology·C F Mountain
Feb 7, 2001·European Journal of Nuclear Medicine·L BarndenC Rowe
Feb 7, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M CymbalistaP Grenier
Aug 3, 2001·Cancer Control : Journal of the Moffitt Cancer Center·C Lloyd, G A Silvestri
Aug 22, 2001·Physics in Medicine and Biology·P PapavasileiouM J Guy
Nov 10, 2001·European Radiology·D W Townsend, S R Cherry
Jul 20, 2002·Annals of Nuclear Medicine·Toru KashiwagiShoji Kondo
Feb 11, 2003·Chest·Klaus L PrenzelArnulf H Hölscher
Mar 1, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Martin WeinmannMichael Bamberg
Aug 22, 2003·Seminars in Nuclear Medicine·Brian F Hutton, Michael Braun
Sep 27, 2003·Radiology·Gerald AntochLutz S Freudenberg
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Jun 23, 2004·Nuclear Medicine Communications·Orazio SchillaciGiovanni Simonetti

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Citations

Dec 13, 2006·Seminars in Nuclear Medicine·Orazio SchillaciRiccardo Santoni
Apr 9, 2008·Seminars in Nuclear Medicine·Youngho SeoBruce H Hasegawa

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