PMID: 9421454Jan 8, 1998Paper

Quantitative analysis of acute axonal pathology in experimental spinal cord contusion

Journal of Neurotrauma
L J Rosenberg, J R Wrathall

Abstract

The major sensorimotor deficits that result from traumatic spinal cord injury (SCI) are due to loss of axons in ascending and descending pathways of the white matter (WM). Experimental treatments administered after a standardized SCI can reduce WM loss and long-term functional deficits. Thus, a significant proportion of WM loss occurs secondary to the mechanical injury and may be a target for therapeutic intervention. Presently, we know little of how and when secondary injury mechanisms operate in the WM after SCI. We therefore used a standardized rat model of clinically relevant contusion injury to examine axonal pathology over the first 24 h by light and electron microscopy. Based on qualitative evaluation of tissue at 15 min, 4 h, and 24 h after a "mild" SCI produced with a weight-drop device (10 g x 2.5 cm), we selected areas from the ventromedial WM at the lesion epicenter for quantitative analyses. We compared axon number and the proportion of axons with various axoplasmic and myelin abnormalities over time after SCI, as well as the effect of axon size on degree of pathology and loss. We found by 4 h postinjury (pi) axonal pathology was more severe than at 15 min and that a significant loss of large diameter axons had occ...Continue Reading

References

Jan 1, 1977·Journal of Neuropathology and Experimental Neurology·C C KaoJ M Bloodworth
Dec 1, 1977·Annals of Neurology·J D Balentine, M Spector
Sep 1, 1975·Experimental Neurology·C L Wakefield, E Eidelberg
Apr 1, 1985·Experimental Neurology·J R WrathallF Harvey
Apr 1, 1985·Experimental Neurology·L J Noble, J R Wrathall
Apr 1, 1972·Journal of Neurosurgery·R L Gilmor, J Mealey
Jan 1, 1974·Cell and Tissue Research·B C Gilson, L J Stensaas
Mar 1, 1983·Journal of the Neurological Sciences·I R Griffiths, M C McCulloch
Mar 1, 1981·Neurochemical Research·W W Schlaepfer, U P Zimmerman
Apr 1, 1994·Journal of Neurotrauma·C W ChristmanJ T Povlishock
Aug 15, 1996·Microscopy Research and Technique·W L Maxwell

❮ Previous
Next ❯

Citations

Oct 10, 2001·Journal of Neuroscience Research·L J Rosenberg, J R Wrathall
May 7, 2005·Acta Neuropathologica·Alejandra C Rodriguez-PaezHelen M Bramlett
May 13, 2006·Cellular and Molecular Neurobiology·Ivo VanickýJán Gálik
Dec 23, 2006·Journal of Neurotrauma·Judith M LytleJean R Wrathall
Jul 28, 2007·Journal of Biomechanical Engineering·Hailing Hao, David I Shreiber
Sep 13, 2013·Journal of Neurotrauma·Adly YacoubBruce E Mathern
Mar 28, 2006·Annals of Neurology·Andrea D Olivas, Linda J Noble-Haeusslein
Dec 16, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Marong FangShu Han
Mar 22, 2001·Experimental Neurology·S D GrossmanJ R Wrathall
Dec 31, 2010·Journal of Neurotrauma·Ahmed Mohammed SulaimanWilliam L Maxwell
Oct 24, 1998·Experimental Neurology·M FraidakisC Spenger
Jul 12, 2016·Electromagnetic Biology and Medicine·Christina L RossBenjamin S Harrison
Jul 10, 2007·Progress in Brain Research·Helen M Bramlett, W Dalton Dietrich
Nov 21, 2007·The Journal of Comparative Neurology·Tom ChaoRanjan Gupta
Aug 5, 2017·Medical & Biological Engineering & Computing·Ehsan Daneshi KohanCarolyn Jennifer Sparrey
Apr 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M BilgenP A Narayana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.