Quantitative analysis of antimicrobial effect kinetics in an in vitro dynamic model.

Antimicrobial Agents and Chemotherapy
Alexander A FirsovS M Navashin

Abstract

Variants of the available methods for estimating antimicrobial effect kinetics in an in vitro dynamic model were analyzed. Two integral parameters characterizing antimicrobial effect duration (TE) and intensity (IE) are suggested to define and analyze the concentration-effect relationships in these models, irrespective of the method of recording. TE is defined by the time from the moment of antibiotic administration to the movement when the bacterial count again reaches its initial level. IE is defined by the area between the microbial growth curves in the presence and absence of an antibiotic. TE and IE were used to quantify the antimicrobial effects of sisomicin on Pseudomonas aeruginosa 58, Escherichia coli 93, and Klebsiella pneumoniae 5056, simulating the pharmacokinetic profiles of the drugs observed following intramuscular administration in therapeutic doses, including the variability of aminoglycoside concentrations in human blood.

References

Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·B Wiedemann, W Hüsing
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·C A White, R D Toothaker
Feb 1, 1984·The Journal of Antimicrobial Chemotherapy·B Wiedemann, A H Seeberg
Sep 1, 1980·Antimicrobial Agents and Chemotherapy·T MurakawaM Nishida
Sep 1, 1982·Journal of Biochemical and Biophysical Methods·A Chen, I Wadsö

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Citations

Apr 14, 2007·Current Infectious Disease Reports·Stephen H Zinner, Alexander Firsov
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·Markus MuellerHartmut Derendorf
Nov 21, 2001·Pharmacotherapy·R L White
Dec 20, 2008·International Journal of Antimicrobial Agents·Elena N StrukovaYury A Portnoy
Dec 3, 2014·International Journal of Antimicrobial Agents·Christian ScheeransCharlotte Kloft
Feb 15, 2001·Current Infectious Disease Reports·Alexander A. Firsov, Stephen H. Zinner

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