Quantitative Analysis of Catecholamines in the Pink1 -/- Rat Model of Early-onset Parkinson's Disease

Neuroscience
Cynthia A Kelm-NelsonMichelle R Ciucci

Abstract

Parkinson's disease (PD) related to homozygous mutations in the Pink1 gene is associated with nigrostriatal dopamine depletion and a wide range of sensorimotor deficits. In humans and animal models of PD, not all sensorimotor deficits are levodopa-responsive. We hypothesized that the underlying mechanisms of locomotion, limb control, and vocal communication behavior include other pathologies. Here, Pink1 -/- rats were treated with an oral dose of levodopa and limb motor and vocal communication behaviors were measured. Levodopa significantly improved some aspects of locomotion but did not improve ultrasonic vocalization intensity or frequency. Catecholamine concentrations in the striatum (SR), substantia nigra (SN), and locus coeruleus (LC) were analyzed to test the hypothesis that behavioral deficits would correlate to altered protein levels. There were no differences in dopamine concentrations in the SR and SN of Pink1 -/- animals compared to wild-type controls. There was a significant increase in norepinephrine concentration in the SN of Pink1 -/- animals. Moreover, an observed decrease in norepinephrine concentrations in the LC is consistent with the hypothesis that early-stage PD includes noradrenergic loss in the brainstem...Continue Reading

References

Feb 18, 1977·Science·S M Antelman, A R Caggiula
Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·C StewartM F Brin
Mar 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A Burleigh-JacobsJ A Obeso
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J D O'SullivanA J Hughes
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·C DromeyA M Lozano
Apr 3, 2002·Journal of Comparative Psychology·Stefan M Brudzynski, Anna Pniak
Jul 3, 2002·Nature Reviews. Neuroscience·M Angela CenciTimothy Schallert
Dec 25, 2002·Neurobiology of Aging·Heiko BraakEva Braak
Jan 28, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·V BonifatiUNKNOWN Italian Parkinson Genetics Network
Jun 18, 2003·Journal of the Neurological Sciences·Joanna D SchaafsmaJeffrey M Hausdorff
Jun 26, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J D SchaafsmaN Giladi
Oct 22, 2003·Physiology & Behavior·Marilyn Y McGinnis, M Vakulenko
Nov 7, 2003·The International Journal of Neuroscience·Mustafa GüvenUner Tan
Apr 6, 2004·Brain Research. Brain Research Reviews·Marc R MarienAlan C Rosenquist
Sep 1, 2004·Cell and Tissue Research·Heiko BraakKelly Del Tredici
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheila M FlemingMarie-Françoise Chesselet
Mar 21, 2007·Journal of Voice : Official Journal of the Voice Foundation·Lucia D'AlatriAnna Rita Bentivoglio
Apr 10, 2007·Biochemical Pharmacology·K S Rommelfanger, D Weinshenker
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tohru KitadaJie Shen
Apr 1, 2009·Behavioral Neuroscience·Michelle R CiucciTimothy Schallert
Jul 8, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ji-feng GuoBei-sha Tang
Jul 30, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Hye Young SungMyung-Gyu Choi
Jun 8, 2011·Frontiers in Systems Neuroscience·Claire DelavilleAbdelhamid Benazzouz
Aug 19, 2011·Journal of Visualized Experiments : JoVE·Aaron M JohnsonMichelle R Ciucci
Dec 23, 2011·Parkinsonism & Related Disorders·Vincenzo Bonifati
Jun 15, 2013·Behavioural Brain Research·Lauren E RingelMichelle R Ciucci
Jun 28, 2014·Neurobiology of Disease·Kuldip D DaveMark A Frasier

❮ Previous
Next ❯

Citations

Jan 29, 2019·Frontiers in Neuroscience·Rose B Creed, Matthew S Goldberg
Feb 18, 2020·Journal of Parkinson's Disease·Rebecca A JohnsonMichelle R Ciucci
Apr 10, 2020·Neuronal Signaling·Fumi Suomi, Thomas G McWilliams
Oct 31, 2020·Frontiers in Neuroscience·Michael KelbermanDavid Weinshenker
Aug 7, 2021·Brain Sciences·Maryann N KraskoMichelle R Ciucci
Sep 23, 2019·Behavioural Brain Research·Julia M MarquisCynthia A Kelm-Nelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.