Quantitative analysis of cell shape and the cytoskeleton in developmental biology

Wiley Interdisciplinary Reviews. Developmental Biology
Hannah G Yevick, Adam C Martin

Abstract

Computational approaches that enable quantification of microscopy data have revolutionized the field of developmental biology. Due to its inherent complexity, elucidating mechanisms of development requires sophisticated analysis of the structure, shape, and kinetics of cellular processes. This need has prompted the creation of numerous techniques to visualize, quantify, and merge microscopy data. These approaches have defined the order and structure of developmental events, thus, providing insight into the mechanisms that drive them. This review describes current computational approaches that are being used to answer developmental questions related to morphogenesis and describe how these approaches have impacted the field. Our intent is not to comprehensively review techniques, but to highlight examples of how different approaches have impacted our understanding of development. Specifically, we focus on methods to quantify cell shape and cytoskeleton structure and dynamics in developing tissues. Finally, we speculate on where the future of computational analysis in developmental biology might be headed. This article is categorized under: Technologies > Analysis of Cell, Tissue, and Animal Phenotypes Early Embryonic Development ...Continue Reading

References

Jun 5, 2004·Science·Dominique C BergmannChris R Somerville
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mats G L Gustafsson
Aug 10, 2006·Nature Methods·Michael J RustXiaowei Zhuang
Aug 12, 2006·Science·Eric BetzigHarald F Hess
Jul 17, 2007·Cell·Thomas GregorDavid W Tank
Nov 26, 2008·Nature·Adam C MartinEric F Wieschaus
Dec 17, 2008·Science·Olivier HamantJan Traas
May 5, 2009·Nature Methods·Guy B BlanchardRichard J Adams
Aug 21, 2009·Nature·Matthias MachacekGaudenz Danuser
Dec 17, 2009·Science Signaling·Rodrigo Fernandez-Gonzalez, Jennifer A Zallen
Jun 15, 2010·Nature Methods·Romain FernandezChristophe Godin
Nov 26, 2010·Nature Cell Biology·Li HeDenise J Montell
Jul 12, 2011·Annual Review of Cell and Developmental Biology·Thomas LecuitEdwin Munro
Jul 14, 2011·Physical Biology·Rodrigo Fernandez-Gonzalez, Jennifer A Zallen
Jan 24, 2012·Methods in Enzymology·Erik MeijeringIhor Smal
Mar 13, 2012·Biophysical Journal·Adam SokolowGlenn S Edwards
Jun 5, 2012·Nature Methods·Uros KrzicLars Hufnagel
Nov 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael A GelbartMatthias Kaschube
Dec 14, 2012·PLoS Computational Biology·Kishore R MosaligantiSean G Megason
May 28, 2013·Cell·Carl-Philipp Heisenberg, Yohanns Bellaïche
Feb 1, 2014·Nature Protocols·Arezki BoudaoudOlivier Hamant
May 13, 2014·Current Biology : CB·Jordan R BeachJohn A Hammer
May 31, 2014·Science·Nikta FakhriChristoph F Schmidt
Jun 21, 2014·Development·Zia KhanMatthias Kaschube
Jun 21, 2014·Development·Teresa Zulueta-CoarasaRodrigo Fernandez-Gonzalez
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Fillip PortSimon L Bullock

❮ Previous
Next ❯

Citations

May 3, 2019·Journal of Biological Engineering·Qinfeng WuJeremiah J Zartman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Methods : a Companion to Methods in Enzymology
Benjamin Lant, W Brent Derry
Methods in Molecular Biology
Sonja Nowotschin, Anna-Katerina Hadjantonakis
Current Opinion in Cell Biology
Ray Keller
The International Journal of Developmental Biology
Stephanie E Lepage, Ashley E E Bruce
© 2022 Meta ULC. All rights reserved