PMID: 2488635Jan 1, 1989Paper

Quantitative analysis of chlortetracycline and related substances by high-performance liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis
N H KhanH Vanderhaeghe

Abstract

Isocratic high-performance liquid chromatography on Zorbax C8 7 microns allows quantitative determination of chlortetracycline, 4-epichlortetracycline, tetracycline, demethylchlortetracycline and isochlortetracycline using a mobile phase containing dimethylsulphoxide, 1 M perchloric acid and water (35:5:60). The minor impurities anhydrochlortetracycline and 4-epianhydrochlortetracycline, which are more strongly retained can be determined using a second isocratic system with a mobile phase containing more organic modifier. The method has been used for the comparison of official standards and for the analysis of a number of commercial samples.

References

Jul 2, 1975·Journal of Chromatography·J H Knox, J Jurand
Feb 26, 1986·Journal of Chromatography·H J Reeuwijk, U R Tjaden
Feb 1, 1982·Journal of Pharmaceutical Sciences·J Hermansson, M Andersson

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Citations

Jan 1, 1989·Journal of Pharmaceutical and Biomedical Analysis·N D WengJ Hoogmartens
Oct 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·P D Bryan, J T Stewart
Jul 15, 2000·Journal of Chromatography. a·H OkaH Matsumoto
Jun 25, 2005·Journal of Chromatography. a·Collin R AndersonWen-Hsin Wu

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