PMID: 7931958Jul 1, 1994Paper

Quantitative analysis of collagen accumulation during protein malnutrition

Journal of Pediatric Surgery
D MistryD Parks

Abstract

It is generally believed that protein malnutrition is detrimental to proper wound healing. However, there is limited evidence in the literature to support this. The authors studied the effect of protein depletion on the accumulation of collagen to determine the quantitative changes taking place in the healing wound. Polytetrafluoroethylene (PTFE) wound cylinders were implanted subcutaneously in 30 male Sprague-Dawley rats. The rats were divided into two groups and fed either chow (C) (n = 12) or an isocaloric protein-free (PF) diet (n = 18). Seven, 14, and 21 days later, the rats were weighed, bled, and wound cylinders harvested. PTFE cylinder collagen content, hematologic parameters, total serum protein, and serum albumin were determined. The rats with the PF diet had significant (P < .001) weight loss at all time-points (day 7, PF = 176.2 +/- 3.2, F = 252.4 +/- 3.8; day 14, PF = 154.8 +/- 3.6, F = 289.3 +/- 9.2; day 21, PF = 150.8 +/- 3.9, F = 307.6 +/- 12.2). Total serum protein was also depleted as compared with controls (P < .001). White blood cell counts were significantly higher on day 7 (PF = 7.5 +/- 0.9, C = 4.4 +/- 0.9, P < .03) in the PF group; however, this was not sustained, and there was no difference between the ...Continue Reading

References

Jun 1, 1977·The Journal of Trauma·L V CrowleyS M Levenson
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Sep 10, 1958·Annals of the New York Academy of Sciences·F D MOORE

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Citations

Jul 16, 2010·Obesity Surgery·Marco D'EttorreRoberto Bracaglia
Dec 24, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marcela OtrantoAndréa Monte-Alto-Costa
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L N JorgensenF Gottrup
Jan 11, 2018·Archives of Plastic Surgery·Yoshiro AbeIchiro Hashimoto

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