PMID: 7931958Jul 1, 1994Paper

Quantitative analysis of collagen accumulation during protein malnutrition

Journal of Pediatric Surgery
D MistryD Parks


It is generally believed that protein malnutrition is detrimental to proper wound healing. However, there is limited evidence in the literature to support this. The authors studied the effect of protein depletion on the accumulation of collagen to determine the quantitative changes taking place in the healing wound. Polytetrafluoroethylene (PTFE) wound cylinders were implanted subcutaneously in 30 male Sprague-Dawley rats. The rats were divided into two groups and fed either chow (C) (n = 12) or an isocaloric protein-free (PF) diet (n = 18). Seven, 14, and 21 days later, the rats were weighed, bled, and wound cylinders harvested. PTFE cylinder collagen content, hematologic parameters, total serum protein, and serum albumin were determined. The rats with the PF diet had significant (P < .001) weight loss at all time-points (day 7, PF = 176.2 +/- 3.2, F = 252.4 +/- 3.8; day 14, PF = 154.8 +/- 3.6, F = 289.3 +/- 9.2; day 21, PF = 150.8 +/- 3.9, F = 307.6 +/- 12.2). Total serum protein was also depleted as compared with controls (P < .001). White blood cell counts were significantly higher on day 7 (PF = 7.5 +/- 0.9, C = 4.4 +/- 0.9, P < .03) in the PF group; however, this was not sustained, and there was no difference between the ...Continue Reading


Jun 1, 1977·The Journal of Trauma·L V CrowleyS M Levenson
Jul 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·H M DelanyS M Levenson
Nov 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·D A Haydock, G L Hill
Nov 1, 1982·The Journal of Surgical Research·W H Goodson, T K Hunt
Sep 10, 1958·Annals of the New York Academy of Sciences·F D MOORE

❮ Previous
Next ❯


Jul 16, 2010·Obesity Surgery·Marco D'EttorreRoberto Bracaglia
Dec 24, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marcela OtrantoAndréa Monte-Alto-Costa
Jul 27, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·L N JorgensenF Gottrup
Jan 11, 2018·Archives of Plastic Surgery·Yoshiro AbeIchiro Hashimoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.