Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET.

European Journal of Nuclear Medicine and Molecular Imaging
Keiichiro YoshinagaNagara Tamaki

Abstract

Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. 82Rb is a generator-produced positron emission tomography (PET) myocardial perfusion tracer that is becoming more widely used. We aimed to (1) develop a method for quantitative assessment of coronary endothelial function using the myocardial blood flow (MBF) response during a cold pressor test (CPT) in smokers, measured using 82Rb PET, and (2) compare the results with those measured using 15O-water PET. MBF was assessed at rest and during the CPT with 82Rb and 15O-water in nine controls and ten smokers. A one-compartment model with tracer extraction correction was used to estimate MBF with both tracers. CPT response was calculated as the ratio of MBF during the CPT to MBF at rest. At rest, measurements of MBF for smokers vs controls were not different using 15O-water (0.86±0.18 vs 0.70±0.13, p=0.426) than they were using 82Rb (0.83±0.23 vs 0.62±0.20, p=0.051). Both methods showed a reduced CPT response in smokers vs controls (15O-water, 1.03±0.21 vs 1.42±0.29, p=0.006; 82Rb, 1.02±0.28 vs 1.70±0.52, p<0.001). There was high reliability [intraclass correlation coefficients: 0.48 (0.07, 0.75)] of MBF measurement between 82Rb and 15O...Continue Reading

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Aug 28, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Riemer H J A Slart
Mar 9, 2012·European Journal of Nuclear Medicine and Molecular Imaging·John O PriorPhilipp A Kaufmann
Mar 31, 2011·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Keiichiro YoshinagaNagara Tamaki
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Jul 23, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Keiichiro YoshinagaNagara Tamaki
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Mar 31, 2021·ESC Heart Failure·Angela S Koh, Jean-Paul Kovalik
Aug 20, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jennifer M RenaudRobert A deKemp

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