PMID: 8592197Nov 1, 1995Paper

Quantitative analysis of dorsal horn cell receptive fields following limited deafferentation

Journal of Neurophysiology
H R Koerber, P B Brown

Abstract

1. To test the hypothesis that subtotal deafferentation of dorsal horn cells can stimulate plastic changes in their receptive fields (RFs), diffuse deafferentation of the cat hindlimb dorsal horn was produced by transection of L7 or L6 and L7 dorsal roots. The following single-unit cutaneous low-threshold mechanoreceptor RF properties were compared between operated and control dorsal horns: 1) distance of RF center from tips of toes, 2) RF length-width ratio; and 3) RF area. 2. In both L7 and L6-L7 rhizotomized animals there was an increased incidence of silent electrode tracks in the most deafferented portion of the hindlimb map (the foot and toe representation). In the rhizotomized L6-L7 animals, there was also an increased incidence of symmetrically placed tracks in deafferented and control dorsal horns, in which cell RFs had no mirror-symmetrical components. In addition, cells in the lateral half of the L6 and L7 dorsal horns exhibited a proximal shift in the location of their RFs. In the rhizotomized L7 animals there was a distal shift of RFs in the L5 segment at long survival times. RFs had lower length-width ratios in L5 and L6 at short survival times and in L6 at long survival times. 3. In intact preparations, dorsal ho...Continue Reading

Citations

Dec 10, 2016·Frontiers in Human Neuroscience·Aude CarteronWei Zhang
Jul 10, 2013·Experimental Brain Research·Yushin KimBum Chul Yoon
Apr 18, 1998·Journal of Neurophysiology·P B BrownJ C Culberson
Aug 1, 1997·Journal of Neurophysiology·L WangP B Brown

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