PMID: 9181432Jun 1, 1997Paper

Quantitative analysis of Drosophila period gene transcription in living animals

Journal of Biological Rhythms
J D PlautzS A Kay

Abstract

To determine the in vivo regulatory pattern of the clock gene period (per), the authors recently developed transgenic Drosophila carrying a luciferase cDNA fused to the promoter region of per. They have now carried out noninvasive, high time-resolution experiments allowing high-throughput monitoring of circadian bioluminescence rhythms in individual living adults for several days. This immediately solved several problems (resulting directly from individual asynchrony within a population) that have accompanied previous biochemical experiments in which groups of animals were sacrificed at each time point. Furthermore, the authors have developed numerical analysis methods for automatically determining rhythmicity associated with bioluminescence records from single flies. This has revealed some features of per gene transcription that were previously unappreciated and provides a general strategy for the analysis of rhythmic time series in the study of molecular rhythms.

References

Sep 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C MagoulasD A Hickey
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P E HardinM Rosbash
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J ZwiebelM Rosbash
Sep 1, 1988·The Journal of Experimental Zoology·S A MonsmaM F Wolfner
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Jun 15, 1995·Genes & Development·Y LiuT Kondo
Feb 1, 1995·Current Opinion in Biotechnology·K V Wood
Jul 1, 1994·Journal of Neurogenetics·A MatsumotoY Chiba
Nov 18, 1994·Science·T KondoM Ishiura
Jan 1, 1993·Journal of Biological Rhythms·D A WheelerJ C Hall
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T KondoC H Johnson
Nov 3, 1995·Cell·S A Kay, A J Millar
Sep 22, 1995·Proceedings. Biological Sciences·A Goldbeter
Dec 1, 1995·Current Opinion in Neurobiology·A Sehgal
Jan 1, 1996·Annual Review of Genetics·J C Dunlap

❮ Previous
Next ❯

Citations

Dec 14, 2006·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Neeraj SalathiaGraham J King
Apr 21, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·P LouC R McClung
Mar 17, 2010·Plant Molecular Biology·Iwanka KozarewaMaria E Eriksson
Jan 7, 1999·Physiology & Behavior·M W HurdG M Cahill
Oct 31, 1998·Current Opinion in Genetics & Development·L D Wilsbacher, J S Takahashi
May 15, 2002·Current Biology : CB·David AlabadíSteve A Kay
Nov 1, 1995·Trends in Biochemical Sciences·A B CubittR Y Tsien
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·M J Dowson-Day, A J Millar
Aug 8, 2001·The Plant Journal : for Cell and Molecular Biology·N SugiyamaK Shimamoto
Nov 26, 2002·The Plant Journal : for Cell and Molecular Biology·Anthony HallAndrew J Millar
Dec 2, 2009·IET Systems Biology·R MoriokaK Horimoto
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rodrigo A GutiérrezGloria M Coruzzi
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bryan Thines, Frank G Harmon
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Neil DalchauAlex A R Webb
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sunghyun HongC Robertson McClung
Dec 1, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthew A JonesStacey L Harmer
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Neil DalchauAlex A R Webb
Nov 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Soledad Francisca UndurragaChristine Queitsch
Aug 15, 2002·Plant Physiology·Patrice A SaloméC Robertson McClung
Oct 12, 2002·Plant Physiology·Todd P Michael, C Robertson McClung
Sep 13, 2002·Plant Physiology·Simon C ThainAndrew J Millar
Dec 18, 2001·Plant Physiology·A HallA J Millar
Jun 14, 2003·Plant Physiology·Todd P Michael, C Robertson McClung
Mar 27, 2007·Plant Physiology·Harriet G McWattersSeth J Davis
May 16, 2008·Plant Physiology·Patrice A SaloméC Robertson McClung
Jul 11, 2008·Plant Physiology·Heather KnightHarriet G McWatters
Apr 22, 2010·Plant Physiology·Xiaodong XuC Robertson McClung
Dec 18, 2010·Plant Physiology·Cory T EllisonStacey L Harmer
Dec 20, 2012·Plant Physiology·Sunghyun HongC Robertson McClung
Jan 12, 2013·Plant Physiology·Yong-Yi ChenKuo-Chen Yeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.