PMID: 6536908Dec 1, 1984Paper

Quantitative analysis of drug-induced tremor in mice

Neuroscience Research
H Shinozaki

Abstract

A method of analyzing tremor in mice was developed using a power spectral analysis of the random current induced by the movement of a magnet attached to a mouse, on a wire coil. The power spectral density function defined the frequency composition of the tremor, and the mean square value of the data in any frequency range of concern was determined. It was possible to determine qualitative differences in the tremor caused by various tremorgenic agents, and to differentiate the drug-induced tremor from spontaneous motor activity. The power spectral densities of the tremorine- and oxotremorine-induced tremors were tentatively expressed as the sum of 3 main components (Cauchy distribution) with different peak frequencies, consisting of the spontaneous motor activity component and two tremor components. On the other hand, the power spectral densities of the harmaline-induced tremor were expressed as the sum of two components with two peak frequencies, and the plots of the power spectral densities versus frequency, consisting of the spontaneous motor activity component and a tremor component. The frequency of the peak spectral density was almost independent of the dose of tremorgenic agents, but changed slightly with the lapse of tim...Continue Reading

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Citations

Mar 6, 2004·Neurotoxicology and Teratology·Tracey E SamsamPhilip J Bushnell
Jun 5, 2004·Parkinsonism & Related Disorders·M Serrano-Dueñas
Dec 11, 2002·Parkinsonism & Related Disorders·P H GordonS Fahn
Jun 6, 2009·European Journal of Pharmacology·Neil E PatersonTaleen Hanania
Jan 1, 1986·The Australian and New Zealand Journal of Surgery·H J Fry
Jan 16, 2021·Journal of Neuroscience Methods·Ayako AjimaShigeyoshi Itohara

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