Quantitative analysis of firing properties of pyramidal neurons from layer 5 of rat sensorimotor cortex

Journal of Neurophysiology
P C SchwindtW E Crill

Abstract

Quantitative aspects of repetitive firing evoked by injected current steps and ramps were studied in layer 5 pyramidal neurons in brain slices of rat sensorimotor cortex to answer the following questions. Do the tonic firing properties of burst-firing and regular-spiking (nonbursting) neurons differ significantly? Does burst firing denote a discrete class of neurons or represent a continuum of firing properties? Is firing rate during the burst of action potentials related to stimulus amplitude? What aspect of the stimulus might the initial firing rate code? How stable are a neuron's firing properties over time? All recorded neurons fired tonically to a long-lasting current above a minimum value, and the tonic firing properties of most neurons were quite similar irrespective of their initial response to a current step. Only a group of high-resistance neurons had significantly different tonic firing properties. When slow current ramps (rising between 0.5 and approximately 20 nA/s) were applied, the relation between firing rate and current during the ramp was very similar to the relation between tonic firing rate and current obtained from long-lasting current steps. Low-resistance cells exhibited three distinct initial responses t...Continue Reading

References

Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Jun 22, 1990·The Journal of Comparative Neurology·Y Chagnac-AmitaiD A Prince
Nov 1, 1989·Journal of Neurophysiology·Y Chagnac-Amitai, B W Connors
Apr 24, 1989·Neuroscience Letters·A Agmon, B W Connors
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Sep 13, 1988·Brain Research·R J MontoroD Jassik-Gerschenfeld
Oct 1, 1980·Journal of Neurophysiology·P D Cheney, E E Fetz
Dec 1, 1982·Journal of Neurophysiology·B W ConnorsD A Prince
Aug 1, 1984·Journal of Neurophysiology·C E StafstromW E Crill
Sep 1, 1993·The Journal of Comparative Neurology·G F Tseng, D A Prince

❮ Previous
Next ❯

Citations

Apr 4, 2006·The Journal of Physiology·Monica A PerezJens B Nielsen
Jan 16, 2009·Nature·Jason S RothmanR Angus Silver
Apr 13, 2012·Journal of Neurophysiology·A V ZaitsevD A Lewis
Nov 10, 2013·PLoS Computational Biology·Stewart HeitmannMichael Breakspear
Oct 29, 2015·Nature Reviews. Neuroscience·Artur LuczakKenneth D Harris
Jun 24, 2016·Journal of Neurophysiology·Amanda K KinnischtzkeDaniel J Simons
Oct 16, 2001·Journal of Neurophysiology·B DoironL Maler
May 31, 2002·Journal of Neurophysiology·Mala M Shah, Dennis G Haylett
Mar 31, 2006·Journal of Neurophysiology·Fabrizio Gabbiani, Holger G Krapp
May 17, 2003·Journal of Neurophysiology·Alexander RauchStefano Fusi
Apr 25, 2006·Journal of Computational Neuroscience·Renaud JolivetWulfram Gerstner
Jun 30, 2006·Journal of Neurophysiology·Giancarlo La CameraStefano Fusi
May 20, 1998·Journal of Neurophysiology·P C Schwindt, W E Crill
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Artur LuczakKenneth D Harris
Aug 31, 2004·Neural Computation·Giancarlo La CameraStefano Fusi
Oct 30, 2004·The Journal of Comparative Neurology·Walther AkemannThomas Knöpfel
Dec 25, 2003·Journal of Physiology, Paris·Ray W TurnerRobert J Dunn
May 15, 2002·Hippocampus·James R MoyerThomas H Brown
Nov 3, 2021·PLoS Computational Biology·Eilam Goldenberg Leleo, Idan Segev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.